摘要
氮酮是一种新型皮肤渗透促进剂,用2,3-~3H-环己-1-酮经化学合成制备了它的氚标记物——~3H-氮酮。氚的分布为4,5,6位占95％,3,7和12′位占5％,其放射性比度和放化纯度分别为1.5×10~3GBq/mmol和95％。~3H-氮酮在正常小白鼠皮肤表面上涂药后,3h血液中放射性达最高峰,在各组织中分布是肌肉最多,其次为肝脏、肾脏和脾脏。
A new enhancer for skin penetration, ~3H-azone is prepared with 2,3-di 3H-cyclohexan-1-one via chemical synthesis. Its specific activity and radio- chemical purity are 1.5×10~3GBq/mmol and 95% respectively. This newly synthesized ~3H-azone is studied for its distribution in rate in different peri- ods. The radioactivities are highest in muscle then in liver, kidney and spleen.
出处
《北京师范大学学报（自然科学版）》
CAS
1988年第4期71-75,共5页
Journal of Beijing Normal University(Natural Science)
基金
国家自然科学基金
关键词
皮肤渗透促进剂
环己酮
氮杂环庚烷-2-酮
氮酮
氚标记
enhancer for skin penetration, cyclohexanone, azacycloheptan-2-one, azone, tritium labelling.
