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Toll样受体与梗阻性肾病肾纤维化关系研究进展 被引量：1

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摘要 梗阻性肾病是泌尿系统常见的疾病之一,而肾间质纤维化是梗阻性肾纤维化进展为终末期肾衰竭的通路,以肾间质中细胞及胶原成分集聚增多、伴有肾小管萎缩或扩张、变形及肾小管和间质毛细血管的丧失为特征.Toll样受体（toll like receptors,TLRs）能够影响梗阻性肾纤维化中上皮-间充质细胞转化以及免疫微环境的调节等过程.随着TLRs及其影响梗阻性肾病肾纤维化机制的研究不断深入,TLRs可能成为预防治疗梗阻性肾病肾纤维化的新靶点,将使梗阻性肾病肾纤维化的防治迈上新的台阶.
作者 陈磊 邵怡
机构地区 上海交通大学附属第一人民医院泌尿外科
出处 《国际泌尿系统杂志》 2016年第2期298-301,共4页 International Journal of Urology and Nephrology
基金 国家自然科学基金（81200504）
关键词 肾疾病 纤维化 TOLL样受体
分类号 R692 [医药卫生—泌尿科学]
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参考文献29

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二级参考文献39

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国际泌尿系统杂志
2016年 第2期

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