5Collombat P, Mansouri A, Hecksher-Sorensen J, et al.Opposing actions of Arx and Pax4 in endocrine pancreasdevelopment[J]. Genes Dev,2003,11(17):2591-2603.
9Szabat M, Lynn FC, Hoffman BG,et al.Maintenance of (3-cellmaturity and plasticity in the adult pancreas: developmentalbiology concepts in adult physiology[J]. Diabetes,2012, 61(6):1365-1371. DOI: 10.2337/dbl 1-1361.
10Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, et al.Conversion of mature human beta-cells into glucagon -producing alpha- cells[J]. Diabetes, 2013,62(7):2471- 2480.DOI: 10.2337/dbl2-1001.
7BOROWIAK M,MELTON D A. How to make beta cells? [J]. Curr Opin Cell Bio1,2009,21:727 -732.
8RICORDI C,EDLUND H. Toward a renewable source of pancreatic betacells[J]. Nat Biotechnol,2008,26:397 -398.
9MCKNIGHT K D, WANG P, KIM S K. Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells[J]. Cell Stem Cell ,2010,6:300-308.