一氧化碳中毒患者心肌损害与迟发脑病的相关性

Correlations of myocardial damage and delayed encephalopathy in carbon monoxide poisoning patients

目的:探讨一氧化碳中毒患者心肌损害与迟发脑病的相关性。方法:选取300例急性一氧化碳中毒患者为研究对象,分为脑病组和非脑病组。脑病组患者80例,合并迟发性脑病;非脑病组患者220例,无发生迟发性脑病。对两组患者的血清心肌损害指标进行检测,并进行相关性分析。结果:脑病组患者的血清CTn T、CK与CK-MB值都明显高于非脑病组,同时心肌酶增高发生率也明显高于非脑病组(P<0.05)。Spearman相关性分析结果显示CTn T、CK与CK-MB值与迟发脑病发生都存在明显正相关性(P<0.05)。结论:一氧化碳中毒患者中迟发脑病的发病率比较高,可导致其血清心肌损害指标表达升高,同时心肌损害与迟发脑病存在明显相关性。

Objective To investigate correlations of myocardial damage and delayed encephalopathy in carbon monoxide poisoning patients. Methods： 300 acute carbon monoxide poisoning patients were selected and divided into encephalopathy group and non-encephalopathy group. 80 cases in encephalopathy group had delayed encephalopathy while 220 cases in non-encephalopathy groupdid not suffered from delayed encephalopathy. The serum myocardial damage indicators were tested and a correlation analysis was performed. Results： The serum CTnT, CK and CK-MB values in encephalopathy group were significantly higher than those of non-encephalopathy group, while the enzymes increased incidence was also significantly higher than that of non-encephalopathy group （P〈0. 05）. Spearman correlation analysis showed CTnT, CK and CK-MB values were significantly positively correlated to the delayed encephalopathy （P〈0. 05）. Conclusions： The delayed encephalopathy incidence rate in the carbon monoxide poisoning patients is relatively high, which can lead to myocardial damage, while there is a significant correlation between myocardial damage and delayed encephalopathy.