艾司西酞普兰联合MECT治疗老年期抑郁症患者的效果观察

Efficacy observation of Escitalopram combined with MECT in senile depression

目的:评价艾司西酞普兰联合无抽搐电休克(MECT)对老年期抑郁症的临床效果和安全性。方法:采用随机方法,将88例老年期抑郁症患者分成研究组和对照组,每组各44例。研究组患者给予艾司西酞普兰联合MECT治疗;对照组患者给予艾司西酞普兰联合增效剂治疗。两组患者共观察6周,再用汉密顿抑郁量表(HAMD)进行评分。在治疗前、1周末、6周末分别评定两组患者治疗前后的疗效。结果:两组患者比较差异有统计学意义(均P<0.05)。艾司西酞普联合MECT的有效率明显高于艾司西酞普兰合并增效剂(P<0.05)。结论:艾司西酞普兰联合MECT治疗老年期抑郁症患者的临床效果较好,治疗时间较短,而且比较安全。

Objective To investigate clinical efficacy and safety of Escitalopram combined with MECT in senile depression.Methods： 88 senile depression patients were randomly divided into study group（44, Escitalopram therapy combined with MECT） andcontrol group（44, Escitalopram therapy combined with synergist）, and the treatment lasted for 6 weeks. The clinical efficacy were assessed by Hamilton depression scale （HAMD）for three times（before and 1 and 6 weeks after the treatment）. Results： The effectiverate of study group was significantly higher than that of control group, and the differences between the two groups was significant （P〈0. 05）. Conclusions： Escitalopram combined with MECT in Senile depression has better efficacy with less time and high safety.