2010–2014年北京地区22家医院抗抑郁药物应用研究

Application analysis on antidepressant drugs of 22 hospitals in Beijing from 2010 to 2014

目的：了解北京地区抗抑郁药物使用情况,为临床合理用药提供参考。方法：采用回顾性分析方法,以WHO推荐的限定日剂量（DDD）作为药物利用研究评价单位,对2010–2014年北京地区22家医院抗抑郁药物的销售金额、DDDs以及DDC进行统计分析。结果：2010–2014年,北京地区22家医院共使用了19种抗抑郁药物;抗抑郁药物的用药金额和DDDs均呈增长趋势;用药金额和DDDs年均增幅分别为14.79%和16.47%;各品种各年度的DDC保持不变。SSRIs和s SNRIs分别占用药金额的60%~70%和20%。DDDs排序前3位是帕罗西汀、氟哌噻吨/美利曲辛复方制剂、西酞普兰或艾司西酞普兰。结论：抗抑郁药物在临床应用日趋增长,以SSRIs和s SNRIs为代表的新型抗抑郁药物已成为一线用药。

Objective： To investigate the status and the development tendency of clinical application of antidepressantsin Beijing area, and provide evidence for rational usage of antidepressants. Methods： Using the analytical method of the defineddaily dose （DDD） recommended by WHO, consumption sum, DDDs and defined daily cost （DDC） of antidepressants in 22 hospitalsin Beijing area from 2010 to 2014 were analyzed retrospectively.Results： Within 5 years, 19 kinds of antidepressants were used.DDDs and consumption sum of antidepressants showed increased trend year by year in 22 hospital of Beijing. Average annual growthrates of consumption sum and DDDs were 14.79% and 16.47% respectively. DDC remained unchanged. Selective serotonin reuptakeinhibitors （SSRIs）, selective serotonin and norepinephrine reuptake inhibitors （sSNRIs） used predominantly. The consumption sum ofSSRIs and sSNRIs accounted for over 60% – 70% and 20% among the total consumption sum of antidepressant drugs respectively.The top 3 drugs in DDDs were paroxetine, flupentixol and melitracen compound tablets, citalopram or escitalopram. Conclusion：Antidepressant drugs played an increasingly important role in clinical treatment. New types of antidepressants, such as SSRIs andsSNRIs, have already become the first-line antidepressants in clinic practice.