红细胞分布宽度与阵发性非瓣膜性心房颤动射频消融后复发的关系

Association between RDW and atrial fibrillation recurrence after radiorequency catheter ablation in patients with paroxysmal non-valvular atrial fibrillation

目的:探讨红细胞分布宽度(RDW)与阵发性非瓣膜性心房颤动(房颤)导管射频消融后复发的关系。方法:入选阵发性非瓣膜性房颤患者73例,均首次行环肺静脉消融术。收集所有患者的RDW、房颤病程、血清非结合胆红素水平、总胆红素水平、左房直径的临床数据。设定术后3个月为空白期。平均随访(17±15)个月。复发定义为术后3个月发生的持续时间>30 s的快速房性心律失常,包括房速、房扑、房颤。采用多元Logistic回归分析RDW与复发的关系。结果:房颤复发24例、未复发49例,复发组患者术前RDW、左房直径、房颤病程、间接胆红素、总胆红素均高于未复发组(P<0.05),经多元Logistics回归显示,左房直径、房颤病程、RDW是房颤消融术后复发的独立危险因素。结论:RDW增高、左房直径增大、房颤病程延长与阵发性非瓣膜性房颤患者导管射频消融后复发有关。

Objective： To investigate the association between red cell distribution width（RDW） and atrial fibrillation recurrence after radiofrequency catheter ablation in patients with paroxysmal non-valvular atrial fibrillation. Methods： 73 patients with paroxysmal nonvalvular atrial fibrillation that undergoing ring plumonary vein radiofrequency catheter ablation were included. RDW, course of atrial fibrillation, left atrium diameter, unconjugated bilirubin, total bilirubin of all patients were carefully collected. Three months after the operation for the blank period was set up. The average follow-up period was（17±15） months. Recurrence was defined as recurrence of atrial fibrillation, atrial flutter, atrial tachycardia which lasted 30 s. Statistic data were analyzed by multiple Logistic regression. Results：Twenty-four patients had atrial fibrillation recurrence relapse. Recurrence group had higher preoperative RDW, bigger left atrial diameter,longer course of atrial fibrillation, higher unconjugated bilirubin, total bilirubin than non-recurrence group（P〈0.05）. Multivariate Logistic regression analysis showed that left atrial diameter, course of disease, RDW were independent risk factors for atrial fibrillation recurrence after radiofrequency catheter ablation. Conclusion： Left atrial diameter, course of atrial fibrillation, and RDW could be associated with recurrence of atrial fibrillation after radiofrequency catheter ablation in patients with paroxysmal non-valvular atrial fibrillation.