青竹汤对气阴两虚,湿热痹阻型成人Still病血清皮质醇水平的影响

Effect of Qingzhu Detection on Cortisol Levels in Serum in Treament of Adult Onset Still's Disease with Deficiency of Qi,Yin and Damp-heat Blockage Type

目的:探讨青竹汤对气阴两虚,湿热痹阻型成人Still病(AOSD)血清皮质醇水平的影响。方法:选取2013年10月—2015年6月符合入选标准的AOSD患者(气阴两虚,湿热痹阻型)60例,随机分为试验组和对照组,各30例,试验组予以青竹汤治疗,每日1剂,bid,对照组予双氯芬酸钠缓释片治疗,每次75 mg,bid。两组患者持续治疗2周,分别记录治疗前后症状体征积分,测定血清皮质醇(CS)水平。疗程结束后第4,8周随访记录患者症状体征积分。结果:与治疗前比较,两组患者的症状体征积分均有明显改善(P<0.01),试验组症状体征积分改善优于对照组(P<0.05),治疗后试验组患者血清CS水平升高(P<0.05),患者症状体征改善程度与血清CS水平呈显著正相关(r=0.609),且症状改善程度对血清CS水平有依存性(P<0.05)。疗程结束后第4,8周随访记录患者症状体征积分,试验组明显优于对照组(P<0.01)。结论:青竹汤可通过改善AOSD患者血清CS水平控制病情。

Objective： To observe the effect of Qingzhu detection on cortisol（ CS） levels in serum during treatment of adult onset Still＇s disease（ AOSD）（ Qi and Yin deficiency and damp-heat blockage type）.Method： Totally 60 eligible patients with AOSD from October 2013 to June 2015 were randomly divided into test group（ n = 30） and control group（ n = 30）. Qingzhu detection,bid for two weeks as a period of treatment was given to 30 patients in test group and diclofenac sodium sustained release tablets（ 150 mg per day,75 mg·time- 1,bid） were given to 30 patients in control group. The treatment course was 2 weeks for both groups. Scores of symptoms and signs were recorded and CS levels in serum were detected before treatment and after treatment. At week 4 and week 8 after treatment,scores of symptoms and signs were also recorded in both test group and control group. Result： Scores of symptoms and signs were significantly improved after treatment in both groups（ P 0. 01）,and scores in test group were obviously superior to those in control group（ P〈 0. 05）. CS level in serum was increased in patients of test group after treatment（ P〈 0. 05）. Improvement degree of symptoms and signs was positively correlated with CS level in serum（ r = 0. 609）,and improvement degree of symptoms had dependence on CS level in serum（ P〈 0. 05）. According to the follow-up records of symptom and sign scores at week 4 after treatment,test group was significantly superior to control group（ P〈 0. 01）. Conclusion： Qingzhu detection can effectively control AOSD by improving the level of CS in serum.