基于数学属性偏序表示原理的《伤寒论》甘草方剂配伍量效群结构知识发现

Knowledge Discovery Method for Group Structure of Glycyrrhizae Radix et Rhizoma Dosage-efficacy in Treatise on Exogenous Febrile Disease Based on Theory of Structural Partial-ordered Attribute Diagram

目的:基于属性偏序表示原理的药物方剂配伍量效群结构图,发现《伤寒论》甘草方药量效关系的相关知识。方法:收集《伤寒论》甘草相关的方剂及条文,进行规范化表达,建立数据库,构建甘草方剂配伍量效群结构图,并从图中进行模式发现,从而整理和研究《伤寒论》甘草方药量效关系的科学内涵。结果:从总述和分述的甘草方剂配伍量效群结构图中,能系统、全面、多层次地展示甘草的方药量效规律。结论:基于数学属性偏序表示原理的群结构知识发现方法能够在已知的中医文献中挖掘对方药量效关系研究有价值的知识,为其规范化、系统化、科学化、现代化传承和拓展提供可鉴之法。

Objective： To discover the knowledge of Glycyrrhizae Radix et Rhizoma dose-response in Treatise on Exogenous Febrile Disease based on the group structure diagram of structural partial-ordered attribute.Method： Formulas and prescriptions about Glycyrrhizae Radix et Rhizoma in the Treatise on Exogenous Febrile Disease were collected to standardize the expression, establish a database, build dose-response group structure diagram of Glycyrrhizae Radix et Rhizoma, and discover the pattern from the diagram. Then the scientific connotation of Glycyrrhizae Radix et Rhizoma dose-response relationship in Treatise on Exogenous Febrile Disease was collected and studied. Result： The dose-response group structure diagram of Glycyrrhizae Radix et Rhizoma could systemically, comprehensively multi-levelly demonstrate the dose-response rules of Glycyrrhizae Radix et Rhizoma. Conclusion： It was concluded that, valuable knowledge on dose-response relationship can be dig outwith the knowledge discoverymethod based on the theory of structural partial-ordered attribute diagram,providing an applicable method for inheritance and development of standardization,systematization,scientization and modernization.