Th17细胞与结直肠癌被引量：6

Th17 cells and colorectal cancer

下载PDF

导出

摘要正常情况下,肠道内辅助性T细胞17(Th17)在维持肠内免疫稳态和抵抗外界病原微生物侵入方面起着重要的作用。然而近来研究发现Th17细胞异常分化、激活、增殖及其分泌的细胞因子(IL-17、IL-22、IL-21、IL-26)是导致结直肠癌发生发展的重要因素。故本文着重对Th17细胞及其分泌的细胞因子在结直肠癌发生发展中所起的作用进行综述并总结了其潜在的机制,为结直肠癌的防治提供新思路。 Under normal condition, T helper 17（Th17） cells play an important role in keeping intestinalimmune homeostasis and resisting to external pathogenic microorganisms invasion. However, recent studies showthat Th17 cells＇ abnormal differentiation and activation and their secreted cytokines（IL-17, IL-22, IL-21, IL-26）have an important role in the development of colorectal cancer. This article focuses on reviewing the role of Th17 cells and their secreted cytokines in the development and advance of colorectal cancer, and summarizes theirpotential mechanism, which will bring some new ideas for the prevention and treatment of colorectal cancer.

作者周倩金弢连晓媛张治针

机构地区安徽中医药大学药学院浙江大学药学院浙江大学海洋学院

出处《免疫学杂志》 CAS CSCD 北大核心 2016年第4期360-364,共5页 Immunological Journal

关键词 TH17细胞细胞因子结直肠癌 Th17 cell Cytokines Colorectal cancer

分类号 R735.34 [医药卫生—肿瘤]

引文网络
相关文献

参考文献1

1葛晓龙,曹裕,王婷婷.肠道内Th17细胞的特征及其在炎症性肠病中的作用[J].免疫学杂志,2014,30(12):1113-1117. 被引量：10

二级参考文献29

1Shale M, Schiering C, Powrie F. CD4(+) T-cell subsets in intestinal inflammation[J]. Immunol Rev, 2013, 252(1): 164- 182.
2Lathrop SK, Bloom SM, Rao SM, et al. Peripheral education of the immune system by colonic cornmensal microbiota[J]. Nature, 2011, 478(7368): 250-254.
3Korn T, Bettelli E, Oukka M, et al. IL-17 and Thl7 cells[J]. Annu Rev Immunol, 2009, 27: 485-517.
4Zhou L, Lopes JE, Chong MM, et al. TGF-beta-induced Foxp3 inhibits T(H) 17 cell differentiation by antagonizing RORgammat function [J]. Nature, 2008, 453(7192): 236-240.
5Zuniga LA, Jain R, Haines C, et al. Thl7 cell development: from the cradle to the grave[J], lmmunol Rev, 2013, 252(1):78-88.
6Ivanov II, Atarashi K, Manel N, et al. Induction of intestinal Thl7 cells by segmented filamentous bacteria[J]. Cell, 2009, 139(3): 485--498.
7Atarashi K, Nishimura J, Shima T, et al. ATP drives lamina propria T(H)17 cell differentiation[J]. Nature, 2008, 455(7214): 808-812.
8Shaw MH, Kamada N, Kim YG, et al. Mierobiota-indueed IL-lbeta, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine[J]. J Exp Med, 2012, 209(2): 251-258.
9Zielinski CE, Mele F, Aschenbrenner D, et al. Pathogen- induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-lbeta[J]. Nature, 2012, 484(7395): 514-518.
10Qiu J, Guo X, Chen ZM, et al. Group 3 Innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora[J]. Immunity, 2013, 39(2): 386-399.