自体富血小板凝胶-羊膜复合物在治疗眼表疾病临床观察

The preliminary clinical studies of using autologous platelet-rich plasma combined with amniotic membrane in ocular surface disease treatment

目的观察自体富血小板凝胶-羊膜复合物治疗难治性眼表面疾病疗效，评价其临床应用价值和意义。方法对2014年1～12月在重庆医科大学附属第一医院眼科就诊的33例43只眼重度眼表疾病患者，采用自体富血小板凝胶联合羊膜移植敷贴治疗。随访1-6月，观察患者眼表的修复情况及症状改善程度。结果患者眼表上皮均得到不同程度修复，自觉症状均有不同程度减轻。19例24只眼化学及热烧伤患者中18例23只眼眼表上皮基本修复，1只眼角膜溶解穿孔。5例10只眼重度干眼自觉症状均有明显改善，上皮修复或部分修复。9例9只眼角膜溃疡5例愈合，3例明显好转，1例无改变。结论自体富血小板凝胶一胶联羊膜是一种新型的羊膜复合物，为难治性眼表面疾病的治疗开辟了一条新的有效途径。

Objective To observe how autologous platelet-rich plasma combined with amniotic membrane may be used in treatment of refractory ocular surface disease, and to evaluate its clinical value and significance. Methods Thirty-three patients （43 eyes） in our hospital were treated with au- tologous platelet-rich plasma combined with amniotic membrane transplantation. As follow-up for one to six months, the patients were observed for their ocular surfaces repair and the improvement of symptoms. Results The ocular surface epitheliums of patients repaired by varied degrees, and pa- tients themselves felt their symptoms were relieved in varied levels, 18 cases （23 eyes） of chemical bums and thermal bums in 19 cases （24 eyes） of ocular surface epithelial basic repair, 1 case of pa- tients with corneal perforation. 5 patients （10 eyes） with severe dry eye symptoms were improved consciously, the ocular surface epitheliums repaired partial or fully. Five eyes of 9 patients 9 eyes with corneal ulcer healing, 3 cases improved significantly, 1 case showed no change. Conclusions Autologous Platelet-Rich Plasma combined with amniotic membrane is a new type of amniotic mem- brane complex, which open up a new effective way of the ocular surface disease treatment.