鼠神经生长因子治疗特发性面神经麻痹的临床研究

Clinical study of mouse nerve growth factor in the treatment of idiopathic facial palsy

目的探讨鼠神经生长因子治疗特发性面神经麻痹的临床疗效。方法将100例面神经麻痹患者随机分为对照组和治疗组,每组各50例。两组均给予常规药物治疗、物理因子及针灸、康复治疗,治疗组在对照组治疗基础上加用鼠神经生长因子肌肉注射,治疗28天后进行疗效评定。结果对照组总有效率为80.00%,治疗组总有效率为96.00%,两组总疗效比较有统计学差异(P<0.05)。治疗后两组患者患侧面神经复合肌肉动作电位的潜伏期均缩短、波幅升高,瞬目反射R1波的潜伏期缩短,较治疗前均有显著改善(P<0.05),鼠神经生长因子治疗组优于对照组(P<0.05)。结论应用鼠神经生长因子联合基础药物、康复理疗及针灸对特发性面神经麻痹疗效显著。

Objective ： To evaluate the clinical efficacy of mouse nerve growth factor in the treatment of idiopathic facial palsy. Methods： 100 cases of facial paralysis were randomly divided into control group and treatment group,50 cases in each group. The two groups were given routine drug therapy,acupuncture,physical factors and rehabilitation treatment,On the basis of the above treatment,the treatment group plus theamount of intramuscular injection of mouse nerve growth factor,After 28 days of treatment,the curative effect was evaluated. Results ： The control group total effective rate was80. 00%,the total efficiency of treatment group was 96. 00%,the difference was significant（ P 〈 0. 05）. The two groups were increased in patients with facial nerve compound muscle action potentiallatency was shortened,the amplitude of blink reflex after treatment,R1 wave latency,improved significantly than before treatment,but the treatment group was more significantly（ P 〈 0. 05）. Conclusion： The basic treatment with nerve growth factors treatment in the facial neuritis has satisfactory curative effect.