抗生物膜感染的群体效应抑制剂

Quorum sensing inhibitors on biofilm formation

生物膜是微生物群落附着在基质或表面并被自身合成的胞外基质包裹形成的复合物。细菌生物膜为细菌提供保护层,阻止抗生素进入,使细菌表现出抗抗生素能力。据临床统计表明,80%病原菌感染与其群体效应(QS)介导的生物膜相关,因此,要根治病原菌的感染,抑制生物膜的形成至关重要。QS分子参与生物膜形成,而QS抑制剂(QSI)能抑制生物膜形成。该文就QSI在抗生物膜方面的进展进行综述。

Biofilms are complexes resulting from microbial sessile communities attached to a substratum or interface and embedded in a self-produced extracellular matrix,which can provide a protective layer for bacteria,block antibiotic entry,and allow bacteria to exhibit antibiotic resistance.Clinical statistics showed that about 80% of microbial infections are associated with quorum sensing-mediated biofilms.Thus it is essential to inhibit the formation of biofilm in order to cure pathogen infections.Quorum sensing（QS） molecules are involved in biofilm formation,while QS inhibitors（QSI） can inhibit biofilm formation.This papers reviews advances of QSI in anti-biofilm.