缺氧及缺氧再复氧环境对成骨细胞影响的研究进展

Recent Advances in the Effects of Hypoxia and Hypoxia Reoxygenation on Osteoblasts

随着社会老年化的加剧,老年性骨质疏松症是高龄患者易发生创伤后骨折的主要原因之一。随着年龄的增加,老年人血管弹性及血红蛋白携氧能力也逐步下降,缺血性股骨头坏死也因此易在老年人群中发生。而成骨细胞代谢的改变是骨质疏松症和缺血性股骨头坏死的主要因素。近年来不少学者已对缺氧以及缺氧再复氧条件下成骨细胞的生理学改变做了详尽的研究,本文就近年来缺氧及缺氧再复氧环境对成骨细胞影响的研究进展作一综述。

With the aging of society intensifies,senile osteoporosis has became an important factor of fractures after the trauma among the elderlies. Along with the age increasing,vascular elasticity and the oxygen-carrying ability of the elderlies has gradually decreased. Therefore,avascular osteonecrosis is more likely to be occurred in the elderlies. The changes of osteoblasts metabolism play the major role in osteoporosis and avascular osteonecrosis. Recently,a lot of studies have been done about metabolism of osteoblasts cells under the conditions of hypoxia and hypoxia-reoxygenation. This review will summarize the recent advances in the effects of hypoxia and hypoxia-reoxygenation on osteoblasts.