鼻敏感颗粒药效学实验研究

Pharmacodynamics Study of Bimingan Granule

目的研究鼻敏感颗粒的抗炎、镇痛及抗过敏作用,为该药的临床运用提供科学依据。方法采用二甲苯致小鼠耳廓肿胀法和大鼠棉球肉芽组织形成法观察鼻敏感颗粒的抗炎作用,采用小鼠热板法观察鼻敏感颗粒的镇痛作用,采用大鼠皮肤被动过敏实验观察鼻敏感颗粒的抗过敏作用。结果鼻敏感颗粒不仅能有效降低小鼠、大鼠急性和慢性炎症的发生(P<0.01),具有良好的抗炎效果;还能有效缓解由外界热刺激引起的中枢性疼痛(P<0.05,P<0.01),具有良好的镇痛作用;并可抑制抗卵白蛋白血清所致的大鼠皮肤蓝斑OD值(P<0.05,P<0.01),具有明显的抗过敏作用。结论鼻敏感颗粒具有良好的抗炎、镇痛和抗过敏效果。

Objective To investigate the anti- inflammatory,analgesic and anti- allergic effects of Bimingan granule,thus to provide theoretical basis for clinical application. Methods The anti- inflammatory effects were observed by the methods of xylene- induced ear- swelling in mice and cotton- ball- induced granuloma in rats. The analgesic effect of the drug was evaluated by hot- plate- induced writhing method,and the anti- allergic effect was evaluated by the method of passive cutaneous anaphylaxis in rats. Results Bimingan granule effectively reduced acute and chronic inflammation in mice and rats（P〈0.01）,showing good anti- inflammatory effects. Besides,it effectively relieved the central pain caused by external heat stimulation（P〈0.05 or P〈0.01）,showing good analgesic effects. Moreover,it reduced the high skin coeruleus OD value caused by the anti- egg albumin serum of rats（P〈0.05 or P〈0.01）,showing obvious anti- allergic effects. Conclusion Bimingan granule has significant anti- inflammatory,anti- allergic and analgesic effects.