摘要
BackgroundCalcific 大动脉的狭窄(作为) 是与动脉粥样硬化和长期的发炎分享类似的一个活跃过程。pathophysiology 这为三个最重要的部件是著名的：发炎，纤维变性和石灰化。单核白血球在每这些过程起一个作用。传播单核白血球在的角色这不是清楚的。现在的学习的目的是学习在传播 apoptotic 之间并且非的一个协会 apoptotic CD14 <sup>+</sup> 单核白血球并且当 features.MethodsWe 在 54 个病人估计了 CD14 <sup>+</sup> 单核白血球和 apoptotic 单核白血球的数字与作为重要(大动脉的阀门区域 0.74 ±；0.27 厘米 <sup>2</sup>) 并且把他们与类似的风险因素和没有瓣膜的疾病作比较到 33 个病人。CD14 <sup>+</sup> 单核白血球和 apoptotic 单核白血球的水平被流动 cytometry.ResultsThere 估计不是在风险因素侧面的差别并且知道在病人之间的冠或外部的脉管的疾病与作为并且控制。病人与是作为与控制相比展出了 CD14 <sup>+</sup> 单核白血球的增加的数字(9.9%±；4.9% 对 7.7%±；3.9% ， P = 0.03 ) 。CD14 <sup>+</sup> 单核白血球数字与年龄和存在和严厉有关作为。在病人与作为，两个 CD14 <sup>+</sup> 单核白血球和 apoptotic 单核白血球是相反地与大动脉的阀门 area.ConclusionsPatients 与有关作为重要增加了传播 CD14 <sup>+</sup> 单核白血球的数字，在单核白血球计数和大动脉的阀门区域之间有反的关联。这些调查结果可以建议那发炎在早阀门损害阶段是起作用的不仅，而且在象石灰化那样的以后的发达阶段什么时候同样是严重的。
BackgroundCalcific aortic stenosis （AS） is an active process sharing similarities with atherosclerosis and chronic inflammation. The pathophysiology of AS is notable for three cardinal components： inflammation, fibrosis and calcification. Monocytes play a role in each of these processes. The role of circulating monocytes in AS is not clear. The aim of the present study was to study an association between cir-culating apoptotic and non apoptotic CD14＋ monocytes and AS features.MethodsWe assessed the number of CD14＋ monocytes and apoptotic monocytes in 54 patients with significant AS （aortic valve area 0.74 ± 0.27 cm2） and compared them to 33 patients with similar risk factors and no valvular disease. The level of CD14＋ monocytes and apoptotic monocytes was assessed by flow cytometry.ResultsThere was no difference in the risk factor profile and known coronary or peripheral vascular diseases between patients with AS and controls.Pa-tients with AS exhibited increased numbers of CD14＋ monocytes as compared to controls （9.9% ± 4.9%vs. 7.7% ± 3.9%,P= 0.03）. CD14＋ monocyte number was related to age and the presence and severity of AS. In patients with AS, both CD14＋ monocytes and apoptotic mono-cytes were inversely related to aortic valve area.ConclusionsPatients with significant AS have increased number of circulating CD14＋ monocytes and there is an inverse correlation between monocyte count and aortic valve area. These findings may suggest that inflammation is operative not only in early valve injury phase, but also at later developed stages such as calcification when AS is severe.
