右美托咪定对异氟醚催眠、镇痛作用的影响

Effects of dexmedetomidine on the hypnosis and analgesia of isoflurane

目的观察右美托咪定对异氟醚催眠、镇痛作用的影响。方法将小鼠随机分为异氟醚（Iso）组、右美托咪定（Dex）组、右美托咪定与异氟醚合用（Dex＋Iso）组，每组10只。采用翻正反射实验，记录各组小鼠的入睡率及入睡潜伏期（sleepinglatentperiod，SL）；采用甩尾实验，测定各组小鼠用药前后的甩尾潜伏期（tail—flicklaten—cy，TFL）。结果在翻正反射实验中，与Iso组相比，Dex＋Iso组小鼠的SL明显缩短（P〈0．01）。在甩尾实验中，与基础痛阈相比，给药后10minDex＋Iso组小鼠TFL明显延长（P〈0．05）；与Iso组相比，给药后20～30minDex＋Iso组小鼠TFL明显延长（P〈0．01）。结论右美托咪定能增强异氟醚的催眠、镇痛作用。

Objective To observe the effects of dexmedetomidine on the hypnosis and analgesia of isoflurane. Methods Mice were randomly divided into three groups （n = 10 ） ： an isoflurane （Iso） group, a dexmedetomidine （Dex） group, and an isoflurane ＋ dexmedetomidine （Iso ＋ Dex） group. Then, the sleeping rate and sleeping latency （SL） were recorded using righting reflex. The tail -flick latency （TFL） of each group was determined by tail -flick test before and after treatment. Results The Iso ＋ Dex group presented markedly shorter SL than the Iso group （P 〈 0.01 ）. Compared with the basal pain threshold, the TFL of the Iso ＋ Dex group was extended 10 min after administra- tion （ P 〈 0.05 ）. Compared with the Iso group, the Iso ＋ Dex group produced markedly extended TFL 20 - 30 rain after administration （ P 〈 0.01 ）. Conclusion Dexmedetomidine can enhance the hypnosis and analgesia of isoflurane.