氟哌利多对异氟醚催眠、镇痛作用的影响

Effects of droperidol on the hypnosis and analgesia of isoflurane

目的观察氟哌利多对异氟醚催眠、镇痛作用的影响。方法将昆明种小鼠随机分为异氟醚组（Iso组）、氟哌利多组（Dro组）、异氟醚与氟哌利多合用组（Iso＋Dro组）。利用翻正反射实验，记录每组小鼠的入睡率；利用甩尾实验测定各组小鼠用药前后的甩尾潜伏期（tail—flicklatency，TFL）。结果在翻正反射实验中，Iso＋Dro组与Iso组相比，小鼠入睡率虽提高但差异无统计学意义（P〉0．05）。在甩尾实验中，与基础痛阈相比，Iso＋Dro组小鼠给药后20～30minTFL增加（P〈0．05），给药后40min明显增加（P〈0．01）；与Iso组相比，Iso＋Dro组小鼠给药后40minTFL明显延长（P〈0．01）。结论氟哌利多能增强异氟醚的镇痛作用。

Objective To observe the effects of droperidol on the hypnosis and analgesia of isoflurane. Methods Kunming mice were randomly divided into three groups： an isoflurane （Iso） group, a droperidol （Dro） group, and an isoflurane ＋ droperidol （Iso ＋ Dro） group. Then, the sleeping rate of each group was recorded using righting reflex. The tail - flick latency （TFL） of each group was determined by tail - flick test before and after treatment. Results The Iso ＋ Dro group presented a higher sleeping rate than the Iso group, despite no statistical difference was found （ P 〉 0.05 ）. Compared with the basal pain threshold, the TFL of the Iso ＋ Dro group was extended 20 to 30 rain after administration （ P 〈 0.05 ）, and increased remarkably 40 min after administration （P 〈 0.01 ）. Compared with the Iso group, the Iso ＋ Dro group produced markedly extended TFL 40 min after administration （P 〈 0. 01 ）. Conclusion Droperidol can en- hance the analgesic effect of isoflurane.