自拟解毒补气利湿方在慢性宫颈炎并发人乳头状瘤病毒感染LEEP术后的应用分析

Analysis on the application of self-made detoxication,tonifying Qi and removing dampness prescription in chronic cervicitis combined with human papillomavirus infection after LEEP

目的探讨自拟解毒补气利湿方治疗慢性宫颈炎并发人乳头状瘤病毒(HPV)感染超高频电波刀(LEEP)术后的临床疗效。方法选取2014年1-12月广元市妇幼保健院收治的慢性子宫颈炎并发HPV感染者84例,随机分为A、B两组,每组各42例,两组均采用LEEP术治疗,A组术后辅以自拟解毒补气利湿方治疗。比较两组临床疗效,高危型HPV负荷量、炎性因子TNF-α、IL-6水平变化情况以及不良反应发生情况。结果 A组临床总有效率为80.95%,B组为54.76%,两组比较,差异有统计学意义(P<0.05)。A组患者不良反应发生率为7.1%,B组为23.8%,两组比较,差异有统计学意义(P<0.05)。两组治疗前高危型HPV负荷量、TNF-α、IL-6水平比较,差异无统计学意义(P>0.05);治疗15 d后,两组高危型HPV负荷量、TNF-α、IL-6水平均有显著下降(P<0.05);且A组下降更为显著(P<0.05)。结论自拟解毒补气利湿方应用于慢性宫颈炎并发HPV感染LEEP术后患者可显著降低高危型HPV负荷量及炎性因子TNF-α、IL-6水平,且临床疗效好,不良反应发生率低,具有较好的临床应用价值。

Objective To explore the clinical efficacy of self-made detoxication, tonifying Qi and removing dampness prescription in treatment of chronic cervieitis combined with human papillomavirus （ HPV ） infection after loop electrosurgical excision procedure （LEEP） . Methods Eighty-four patients with chronic cervicitis combined with HPV infection were selected from the hospital from January to December in 2014, then the patients were randomly divided into group A and group B, 42 patients in each group. The patients in the two groups were treated by LEEP, and the patients in group A were treated by self-made detoxication, tonifying Qi and removing dampness prescription after LEEP. The clinical effects, high-risk HPV loads, changes of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） , the incidence rates of adverse reactions in the two groups were compared. Results The total clinical effective rates in group A and group B were 80. 95% and 54. 76% , respectively, there was statistically significant difference between the two groups （ P〈0. 05 ） . The incidence rates of adverse reactions in group A and group B were 7.1% and 23.8% , respectively, there was statistically significant difference between the two groups （ P〈0. 05 ） . Before treatment, there was no statistically significant difference in high-risk HPV load, TNF-ct and IL-6 levels be- tween the two groups （P〉0. 05） ; at 15 days after treatment, high-risk HPV loads, TNF-α and IL-6 levels in the two groups decreased significantly （ P〈0. 05 ） , especially in group A （ P〈0. 05 ） . Conclusion Self-made detoxication, tonifying Qi and removing dampness prescription can significantly reduce high-risk HPV load and TNF-α, IL-6 levels of patients with chronic cervicitis combined with HPV infection after LEEP, the clinical efficacy is good, the incidence rates of adverse reactions are low, so the clinical application value is high.