细辛脑注射液联合多索茶碱治疗儿童支气管哮喘急性发作的临床效果

Clinical effect of asarone injection combined with doxofylline in treatment of acute attack of bronchial asthma among children

目的分析细辛脑注射液和多索茶碱联合治疗儿童支气管哮喘急性发作的临床效果。方法随机选取2011年1月1日-2015年1月1日期间的60例儿童支气管哮喘急性发作患儿,将接受基础综合治疗的患儿设为对照组(30例),接受细辛脑注射液和多索茶碱联合治疗的患儿设为试验组(30例)。观察并比较两组临床治疗结果。结果对照组患儿的呼吸困难消失时间、咳嗽消失时间、哮鸣音消失时间和住院时间分别为(4.98±1.32)d、(5.71±1.43)d、(6.44±1.30)d和(7.57±1.21)d,均长于试验组患儿[(2.11±0.91)d、(3.01±0.45)d、(4.21±0.54)d、(5.77±0.64)d],差异均有统计学意义(t=5.45,P<0.05;t=6.37,P<0.05;t=7.52,P<0.05;t=6.43,P<0.05)。试验组的治疗有效率(96.67%)优于对照组(73.33%),差异有统计学意义(χ2=5.81,P<0.05)。结论细辛脑注射液和多索茶碱联合治疗儿童支气管哮喘急性发作的效果理想,临床症状明显缓解,不良反应少,可考虑于合理范围内加大推广与应用。

Objective To analyze the clinical effect of asarone injection combined with doxofylline in treatment of acute attack of bronchial asthma among children. Methods Sixty children with acute attack of bronchial asthma were randomly selected from February 1, 2011 to January 1, 2015. Thirty children in control group were treated by basic and comprehensive therapy, while thirty children in experimental group were treated by asarone injection combined with doxofylline. The clinical effects in the two groups were observed and compared. Results In control group, dyspnea disappearance time, cough disappearance time, wheezing tale disappearance time, and hospitalization time were （4. 98±1.32） days, （5.71±1.43） days, （6.44±1.30） days, and （7. 57±1.21） days, respectively, which were statistically significantly longer than those in experimental group [ （2. 11±0. 91） days, （3.01±0.45） days, （4. 21±0. 54） days, （5.77_±0. 64） days] （t= 5.45, P〈0. 05 ; t=6. 37, P〈0. 05 ; t=7.52, P〈0. 05 ; t=6.43, P〈0. 05） . The effective rate in experimental group was 96. 67% , which was statistically significantly higher than that in control group （73.33%） （X2 =5.81, P〈0. 05 ） . Conclusion The clinical effect of asarone injection combined with doxofylline in treatment of acute attack of bronchial asthma among children is good, the symptoms are relieved obviously, the adverse reactions are few, which can he promoted and applied within a reasonable range.