595nm脉冲染料激光联合强脉冲光治疗酒渣鼻31例临床观察

Combination of 595nm Pulsed Dye Laser and Intense Pulsed Light in Treatment of Rosacea

目的评价595nm脉冲染料激光联合强脉冲光治疗丘疹脓疱型酒渣鼻的临床疗效和安全性。方法将入选的89例酒渣鼻患者随机分成3组。治疗组（31例）予595nm脉冲染料激光治疗3次后，再予强脉冲光治疗2次。对照1组（29例）予强脉冲光治疗5次。对照2组（29例）予E光（Electric Light Synergy）治疗5次。全部患者每次治疗间隔时间为3～4周，治疗结束后2个月时观察疗效。结果治疗组有效率为93．10％，高于对照1组和对照2组的有效率（82．76％，78．57％），差异均有统计学意义（P均〈0．01）。治疗结束后均未出现色素沉着、瘢痕等不良反应。结论595nm脉冲染料激光联合强脉冲光治疗丘疹脓疱型酒渣鼻疗效显著，且安全有效，不良反应小，值得临床医生选用。

Objective To observe the therapeutic effects of 595 nm pulsed dye laser （PDL） combined with intense pulsed light （IPL） in the treatment of papulopustular rosacea. Method A total of 89 rosacea patients were randomly divided into 3 groups： 31 patients in experiment group were treated with 595 nm PDL for 3 times and PDL combined with IPL for 2 times ; 29 patients in control group 1 treated only with IPL for 5 times ; 29 patients in Control group 2 treated only with Aurora Electric Light Synergy for 5 times. The treatment intervals were 3 - 4 weeks. The therapeutic effect of the patients were observed after 2 months of the treatment. Result The effective rate of experimental group was 93.10%. There was a significant statistic difference between experimental group and control group 1 （ P 〈 0.05 ） and control group 2 （ P 〈 0.01 ）. Pigmentation, scar and other adverse reactions did not happen after the treatment. Conclusion The therapeutic effects of the treatment of papulopustular rosacea with 595 nm PDL combined with IPL was significant. The combination treatment was safe and effective and had less side effect. It is worthy of consideration for clinical use.