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Cellular functions of MLL/SET-family histone H3 lysine 4 methyltransferase components

Cellular functions of MLL/SET-family histone H3 lysine 4 methyltransferase components
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摘要 The MLL/SET family of histone H3 lysine 4 methyltransferases form enzyme complexes with core subunits ASH2L, WDR5, RbBP5, and DPY-30 （often abbreviated WRAD）, and are responsible for global histone H3 iysine 4 methylation, a hallmark of actively transcribed chromatin in mammalian cells. Accordingly, the function of these proteins is required for a wide variety of processes including stem cell differentiation, cell growth and division, body segmentation, and hematopoiesis. While most work on MLL-WRAD has focused on the function this core complex in histone methylation, recent studies indicate that MLL-WRAD proteins interact with a variety of other proteins and IncRNAs and can localize to cellular organelles beyond the nucleus. In this review, we focus on the recently described activities and interacting partners of MLL-WRAD both inside and outside the nucleus. The MLL/SET family of histone H3 lysine 4 methyltransferases form enzyme complexes with core subunits ASH2L, WDR5, RbBP5, and DPY-30 （often abbreviated WRAD）, and are responsible for global histone H3 iysine 4 methylation, a hallmark of actively transcribed chromatin in mammalian cells. Accordingly, the function of these proteins is required for a wide variety of processes including stem cell differentiation, cell growth and division, body segmentation, and hematopoiesis. While most work on MLL-WRAD has focused on the function this core complex in histone methylation, recent studies indicate that MLL-WRAD proteins interact with a variety of other proteins and IncRNAs and can localize to cellular organelles beyond the nucleus. In this review, we focus on the recently described activities and interacting partners of MLL-WRAD both inside and outside the nucleus.
作者 J. K. Bailey Dzwokai Ma
机构地区 Department of Molecular Neuroscience Research Institute
出处 《Frontiers in Biology》 CAS CSCD 2016年第1期10-18,共9页 生物学前沿（英文版）
关键词 H3K4MT histone H3 lysine 4 methyltransferase WDR5 RbBP5 ASH2L DPY-30 SET MLL WRAD Oct4 MYC cell biology protein lysine methylation H3K4MT, histone H3 lysine 4 methyltransferase, WDR5, RbBP5, ASH2L, DPY-30, SET, MLL, WRAD, Oct4,MYC, cell biology, protein lysine methylation
分类号 Q78 [生物学—分子生物学] S511 [农业科学—作物学]
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Frontiers in Biology
2016年 第1期

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