转移性乳腺癌原发病灶切除术的临床研究

Clinical Study on Primary Tumor Resection in Patients with Metastatic Breast Cancer

目的:探讨转移性乳腺癌原发病灶切除术的临床应用效果。方法:136例乳腺癌患分为手术治疗组(A组)与保守治疗组(B组),A组84例,B组52例,分析并比较两组患者一般资料、肿瘤进展及生存时间。结果:两组患者T4期肿瘤、淋巴结转移N3期、HR-阳性、Her-2-阳性、三阴性乳腺癌、内脏转移、骨转移、脑转移等发生率对应比较均无显著统计学差异(P<0.05);A组患者发生局部进展明显少于B组(P<0.05)。A组平均生存时间、平均无进展生存时间均显著长于B组(P<0.01)。A组术前证实转移患者平均生存时间、无进展生存时间与B组比较无显著统计学差异(P>0.05);结论:切除转移性乳腺癌患者原发病灶能够有效提高患者平均生存时间与无进展生存时间。

[ABSTRACT]Objective:To investigate the clinical effect of the resection of primary lesion in patients with metastatic breast cancer. Methods: 136 cases of breast cancer patients were divided into operation group and conservative treatment group, 84 cases in operation group, 52 cases in conservative treatment group, and the general data, tumor progression and survival time of two groups were analyzed and compared. Results: There was no significant difference between the 0.05 groups of patients with T4, N3 positive, HR- positive, Her-2- positive, three negative breast cancer, visceral metastasis, bone metastasis, brain metastasis, and other significant differences (P<0.05); the local progress in surgical treatment group was significantly less than that of the conservative treatment group (P<0.05). The average survival time and progression free survival time in the surgical treatment group were significantly longer than that in the conservative treatment group (P<0.01). The average survival time and progression free survival time of patients with operation treatment group were not significantly different from that of the conservative treatment group (P>0.05). Conclusion:The patients with metastatic breast cancer can effectively improve the average survival time and the time of progression free survival.