荆州区农村初发糖尿病患者胰岛功能跟踪调查

Follow-up Investigation on Islet Function of Rural Patients with Primary Diabetes Mellitus in Jingzhou District

目的:通过对荆州区初发糖尿病患者的胰岛功能进行跟踪观察,探讨初发糖尿病患者胰岛功能的变化特点。方法:选取荆州区初发糖尿病患者220例作为观察对象,跟踪随访12个月。在就诊后的3个月、6个月及12个月时,全部患者检测血糖变化、C-肽释放量,计算胰岛素分泌指数(HOMA-β)及胰岛素抵抗指数(HOMA-IR),观察总结患者的胰岛功能变化特点。结果:1通过药物治疗,患者血糖在3个月时基本达标,6个月及12个月时,患者的血糖水平未见明显波动;2随访期间,糖尿病患者C-肽释放量持续降低,且在就诊后3个月内,C-肽释放量下降明显,与就诊后6个月时及12个月时比较,差异有统计学意义(P<0.05)。3随访期间,糖尿病患者胰岛素放量持续降低,就诊后3个月内下降最明显,差异有统计学意义(P<0.05);4随访期间,糖尿病患者岛素分泌指数持续降低,胰岛素抵抗指数持续升高,且与6个月时和12个月时比较,3个月时变化幅度最为显著(P<0.05)。结论:随着病程的延长,初发糖尿病患者胰岛功能总体上降低,二者具有显著相关性,且3个月内患者的胰岛功能下降最为显著。

Objective:To study the characteristics of islet function change in patients with incipient diabetes through follow-up investigation on islet function of rural patients in Jingzhou District Methods:220cases of patients with primary diabetes mellitus in Jingzhou District had been selected for 12 months follow-up.Blood sugar changes,c-peptide release,insulin secretion indexes(HOMA-beta)and insulin resistance indexes(HOMA IR)had been observed respectively after 3months,6months and12 months.And then characteristics of islet function change in patients had been summarized.Results:1By drug treatment,blood sugar of the patients was up to standard in 3 months,no obvious fluctuation in 6months and 12months;2 During follow-up,c-peptide release of the patients decreased obviously in three months after treatment,and there were statistically significant differences in comparison with the release in 6 months and 12 months(P<0.05).3During follow-up,insulin capacity decreased continuously after treatment and reached the lowest level in three months,the difference being statistically significant(P <0.05);4During follow-up,HOMA-βof the patients continued to fall while HOMA-IR continued to rise with the most significant variations in 3 months(P<0.05).Conclusion:With the extension of the disease course,the islet function of the incipient diabetic patients gradually decreases,there being significant correlation.And the islet function of the patients can reach the lowest in 3months.