自噬因子Beclin 1和LC3表达与胃癌临床病理特征的相关性研究

Correlation Study of Expression of Autophagic Factors Beclin 1 and LC3 and Clinicopathological Features in Gastric Cancer

目的 探讨自噬因子Beclin 1和LC3表达与胃癌临床病理特征的相关性。方法 采用免疫组织化学方法,检测胃癌组织中自噬因子Beclin 1和LC3的表达情况。结果 Beclin 1蛋白在胃癌组织中的表达率为42.5%（51/120）,在癌旁组织其表达率为93.3%（112/120）,两者比较有显著性差异（χ^221.3,P〈0.05）;LC3蛋白在胃癌组织中的表达率为90.0%（108/120）,明显高于癌旁组织的表达率（29.3%,34/120）,两者有显著性差异（χ^224.8,P〈0.05）。Beclin 1和LC3蛋白表达与胃癌肿瘤分化程度和淋巴结转移密切相关,P〈0.05。结论 自噬因子Beclin1和LC3表达可能与胃癌的发生发展有关。

Objective To investigate the expression of autophagic factors Beelin 1 and LC3 and elinieopathological features in gastric cancer. Methods By immunohistochemical method,the expression of Beclin 1 and LC3 in gastric cancer tissues were detected. Results Beclin 1 protein expression of gastric carcinoma was 42.5% （51/120）, and of adjacent tissues was 93.3% （112/120） ,there was significant difference （χ^2= 21.3, P 〈 0.05 ） ; LC3 protein expression in gastric carcinoma was 90.0% （108/120） ,which was significantly higher than that of adjacent tissues （29.3% , 34/120） , there was significant difference （ χ^2= 24.8 ,P 〈 0.05 ）. Beclin 1 and LC3 protein expression were closely related to the degree of differentiation and lymph node metastasis, P 〈 0.05. Conclusion The expression of Beclinl and LC3 are related to carcinogenesis and development of gastric cancer.