新辅助放化疗联合手术治疗老年晚期食管癌患者的安全性及远期疗效分析

Safety and Long-term Efficacy of Neoadjuvant Chemotherapy Combined with Surgical Treatment for Elderly Patients with Advanced Esophageal Cancer

目的探讨新辅助放化疗联合手术在对老年晚期食管癌患者的安全性及远期疗效的分析。方法将80例食管癌老年患者,随机分为对照组和观察组,每组各40例,观察组手术前采用新辅助放化疗后,再进行手术治疗;对照组直接进行手术治疗。结果观察组有效率达到80.0%,明显高于对照组的30.0%(P<0.05),并且患者在治疗后,恶心呕吐、骨髓抑制以及食管炎的发生率明显低于对照组(P<0.05)。随访结果表明观察组总复发率明显低于对照组(P<0.05);对肿瘤的局部控制率以及患者的生存率明显优于对照组,两者有明显统计学意义(P<0.05)。结论新辅助放化疗在提高老年食管癌患者手术治疗效果,对肿瘤的局部控制、患者生存率以及减少肿瘤的复发和转移有着积极的意义。

Objective To investigate the safety and long-term efficacy of neoadjuvant chemotherapy combined with surgery for elderly patients with advanced esophageal cancer. Methods 80 elderly patients with esophageal carcinoma were randomly divided into the control group and the observation group,40 cases in each group. The control group was treated by operation, the observation group received neoadjuvant chemotherapy before the surgery. Results Effective rate in the observation group was 80.0%, and was significantly higher than that of the control group, 30.0% （ P 〈 0.05 ）. After the treatment, nausea and vomiting, bone marrow suppression and esophagitis incidence in the observation group were significantly lower than those of the control group （P 〈 0.05）. The results of follow-up showed that the total recurrence rate in the observation group was significantly lower than that of the control group （ P 〈 0.05 ） ; local control rate and survival rate in the observation group were significantly better than those of the control group, there had obvious statistical difference （ P 〈 0.05 ）. Conclusion Neoadjuvant chemotherapy can improve the efficacy of surgery for elderly patients with esophageal cancer, it has positive significance in tumor control, survival rate of patients and reduce the recurrence and metastasis.