靶控输注丙泊酚与七氟烷吸入麻醉对老年肿瘤患者认知功能的影响

The Effect of Target-controlled Infusion with Propofol and Inhalation of Sevoflurane Anesthesia on Cognitive Function in of Elderly Tumor Patients

目的探讨靶控输注丙泊酚与七氟烷吸入麻醉对老年肿瘤患者认知功能的影响。方法将80例老年肿瘤患者,随机分为对照组(七氟烷吸入麻醉)和观察组(靶控输注丙泊酚麻醉),每组各40例。根据简易智力状态检查表(MMSE)评估和比较2组术前,术后1 h、3 h、6 h、12 h、24 h MMSE评分变化情况并观察2组麻醉恢复、不良反应、满意度。结果与术前相比,对照组术后1 h、3 h、6 h MMSE评分及观察组术后1 h、3 h MMSE评分均明显降低,P<0.05;与对照组术后相比,观察组术后1 h、3 h、6 h MMSE评分均较高,P<0.05。与对照组相比,观察组术后睁眼时间、拔管时间、应答时间均明显缩短,P<0.05。与对照组相比,观察组恶心呕吐、眩晕等不良反应发生率均显著降低,麻醉满意度明显提高,P<0.05。结论靶控输注丙泊酚麻醉对老年肿瘤患者术后认知功能影响较小,麻醉满意度、安全性均较高。

Objective To study the effect of target-controlled infusion with propofol and inhalation of sevoflurane anesthesia on cognitive function of in elderly tumor patients. Methods The 80 elderly tumor patients during the Feb 2014 to Feb 2015 were randomizedly divided into the control group （ inhalation of sevoflurane anesthesia） and the observation group （ target- controlled infusion with propofol anesthesia） according to the random number method,40 patients per group. According to the mini mental state examination （MMSE）, the MMSE scores in the two groups were evaluated and compared before operation on pre-and 1 h ,3 h ,6 h, 12 h ,24 h post-after operation. The anesthesia recovery, adverse reactions and satisfaction degree in the two groups were observed and compared. Results Compared with before the pre-operation,the MMSE scores on 1 h,3 h,6 h after operation in the control group and the MMSE scores on 1 h,3 h inafter operation in the the observation group were significantly decreased （P 〈 0.05 ） ;compared with the control group, the MMSE scores on 1 h ,3 h,6 h after operation in the observation group were sig- nificantly increased （ P 〈 0.05 ）. Compared with the control group, the awake time, extubation time, response time in the observa- tion groupwere significantly shortened in the observation group （ P 〈 0.05 ）. Compared with the control group, the incidence of ad- verse reactions such as nausea and vomiting, dizziness was in the observation group significantly reduced, and the anesthesia satis- faction degree was obviously improved in the observation group （ P 〈 0.05 ）. Conclusion The effect of target-controlled infusion with propofol anesthesia on postoperative cognitive function of elderly tumor patients is smaller with higher anesthesia satisfaction and safety.