氟哌噻吨美利曲辛在冠心病介入术后的应用价值

The application value of flupentixol - melitracen after percutaneous coronary intervention

目的探讨冠心病介入术后应用氟哌噻吨美利曲辛对患者近期及远期疗效的影响。方法选取拟进行经皮冠状动脉介入术（PCI）治疗的冠心病患者86例，采用随机数字表法分为研究组与对照组各43例，对照组术后给予常规治疗，研究组在对照组基础上给予氟哌噻吨美利曲辛治疗，观察两组治疗1个疗程心理状态变化及近期疗效，出院后随访1年，观察两组心血管不良事件发生情况。结果研究组和对照组术后治疗1个疗程后汉密尔顿焦虑量表（HAMA）及汉密尔顿抑郁量表（HAMD）评分分别为（7．46±2．53）分和（15．74±3．16）分，（8．03±1．97）分和（16．42±3．67）分，研究组两项指标均低于对照组（t=13．413、13．208，均P〈0．01）；研究组总有效率为97．67％，高于对照组的81．40％（χ^2=6．081，P〈0．05）。两组有效患者随访1年，研究组心血管不良事件总发生率为6．67％，低于对照组的42．86％（χ^2=9．564，P〈0．05）。结论冠心病介入术后给予氟哌噻吨美利曲辛可有效改善患者焦虑、抑郁情绪，提高PCI术近期治疗效果，降低心血管不良事件发生率，值得临床推广。

Objective To investigate the short and long - term effects of flupentixol - melitracen after percu- taneous coronary intervention（PCI）. Methods 86 patients with coronary heart disease who would be given PCI were randomly divided into 43 cases of the study group and 43 cases of the control group. The control group was given conventional treatment after surgery, the study group was given flupentixol - melitracen on the basis of the control group. After one course, the mental status changes and short - term effect were observed. All the patients had been follow -up for 1 year to observe the occurrence of cardiovascular events. Results After one course, the HAMA and HAMD in the study group and the control group were （7.46±2.53 ） points and （ 15.74±3.16） points, （ 8.03±1.97 ） points and （ 16.42±3.67） points respectively, which in the study group were lower than the control group （ t = 13. 413,13. 208, all P 〈 0.01 ）. The total effective rate of the study group was 97.67%, which was higher than 81.40% of the control group （χ^2= 6.081, P 〈 0.05 ）. During follow - up, the incidence rate of adverse cardiovascular events in the study group was 6.67% ,which was lower than 42.86% of the control group （χ^2= 9. 564,P 〈 0.05）. Conclusion The flupentixol - melitracen can effectively improve anxiety and depression, improve the recent thera- peutic effect of PCI, reduce the incidence of cardiovascular events,which worthy of promotion after PCI.