灯盏细辛合剂联合胞二磷胆碱治疗青光眼视神经萎缩的疗效观察

Clinical observation of Dengzhanxixin Mistura combined with citicoline in treatment of glaucoma optic atrophy

目的探讨灯盏细辛合剂联合胞二磷胆碱治疗青光眼视神经萎缩的临床疗效。方法选择2014年8月—2015年8月三峡大学第一临床医学院收治的青光眼视神经萎缩患者84例,按照治疗方法分为对照组和治疗组,每组各42例。对照组球后注射胞二磷胆碱注射液,2 m L/次,每隔1 d注射1次,20次为1个疗程。治疗组在对照组治疗基础上口服灯盏细辛合剂,10 m L/次,3次/d,40 d为1个疗程。两组患者均连续治疗2个疗程。观察两组患者的临床疗效,同时比较两组视野缺损、P_(100)波潜伏期、视力提高行数的变化。结果治疗后,对照组和治疗组总有效率分别为73.81%、90.48%,两组比较差异有统计学意义(P<0.05)。与治疗前相比,治疗后两组患者视野缺损、P_(100)潜伏期均显著减小,同组治疗前后差异具有统计学意义(P<0.05);但治疗组减小的程度更明显,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组视力的视力提高行数较对照组高,两组比较差异具有统计学意义(P<0.05)。结论灯盏细辛合剂联合胞二磷胆碱医治青光眼视神经萎缩临床疗效显著,可促进患者视力恢复,改善视野缺损,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Dengzhanxixin Mistura combined with citicoline in treatment of glaucoma optic atrophy. Methods Patients（84 cases） with glaucoma optic atrophy in the First Clinical Medical College of Three Gorges University from August 2014 to August 2015 were enrolled in this study. According to the different treatment plans, patients were divided into treatment group（42 cases） and control group（42 cases）. The patients in the control group were iv administered with Citicoline Injection by postocular tissue proper, 2 mL/time, once every other day, and 20 times were as one course of treatment. The patients in the treatment group were po administered with Dengzhanxixin Mistura on the basis of control group, 10 mL/time, three times daily, and 40 d was as one course of treatment. Patients in two groups were treated for two courses. After treatment, the clinical efficacy was evaluated, and the changes of visual field defect, P100 wave incubation period, and the lines number of eyesight improvement in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.81% and 90.48%, respectively, and there were differences between two groups（P〈0.05）. Compared with those before treatment, after treatment, visual field defect and P100 wave incubation period in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. The decreased extent in the treatment group was more significantly, and there were differences between two groups（P〈0.05）. The line numbers of eyesight improvement in treatment group was better than that of control group, with significant difference between two groups（P〈0.05）. Conclusion Dengzhanxixin Mistura combined with citicoline has distinct clinical effect in treatment of glaucoma optic atrophy, and can promote the visual acuity, also can improve visual field defect, which has a certain clinical application value.