丹红注射液联合血必净注射液治疗严重脓毒症的临床研究

Clinical study on Danhong Injection combined with Xuebijing Injection in treatment of severe sepsis

目的探讨丹红注射液联合血必净注射液治疗严重脓毒症的临床疗效。方法收集2011年2月—2015年6月天津中医药大学第二附属医院收治的严重脓毒症患者80例,随机分为对照组和治疗组,每组各40例。对照组静脉滴注血必净注射液,50 m L加入100 m L生理盐水中,2次/d。治疗组在对照组治疗的基础上静脉滴注丹红注射液,20 m L加入5%葡萄糖注射液250 m L,1次/d。两组均连续治疗7 d。观察治疗前后两组患者体温(T)、心率(HR)、呼吸频率(R)、APACHEⅡ评分、白细胞数(WBC)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、C反应蛋白(CRP)、降钙素原(PCT)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、尿素氮(BUN)、肌酐(Cr)、磷酸激酶同工酶(CPK)的变化及两组患者治疗7 d的病死率。结果治疗后,两组患者T、HR、R、APACHEⅡ评分、WBC、TNF-α、IL-6、IL-10、CRP、PCT、ALT、AST、BUN、Cr和CPK均显著降低,同组治疗前后差异具有统计学意义(P<0.05);但治疗组降低的程度更明显,两组比较差异有统计学意义(P<0.05)。治疗后,对照组和治疗组的病死率分别为40.0%、27.5%,两组病死率比较差异有统计学意义(P<0.05)。结论丹红注射液联合血必净注射液治疗严重脓毒症临床疗效显著,能明显改善患者的各项生命指标、炎症指标及生化指标,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Danhong Injection combined with Xuebijing Injection in treatment of severe sepsis. Methods Patients（80 cases） with severe sepsis in Department of Emergency of Second Affiliated Hospital of Tianjin University of TCM from February 2011 to June 2015 were randomly divided into control（n = 40） and treatment（n = 40） groups. The patients in the control group were iv administered with Xuebijing Injection, 50 mL added into normal saline 100 mL, twice daily. The patients in the treatment group were iv administered with Xuebijing Injection on the basis of the control group, 20 mL added into 5% glucose injection 250 mL, once daily. The patients in two groups were treated for 7 d. After treatment, the changes of T, HR, R, APACHEⅡ scores, WBC, TNF-α, IL-6, IL-10, CRP, PCT, ALT, AST, BUN, Cr, and CPK in two groups before and after treatment were compared, and fatality rates in 7 d of the treatment in two groups were compared. Results After treatment, T, HR, R, APACHEⅡ scores, WBC, TNF-α, IL-6, IL-10, CRP, PCT, ALT, AST, BUN, Cr and CPK in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the fatality rates in the control and treatment groups were 40.0% and 27.5%, respectively, and there were differences between two groups（P〈0.05）. Conclusion Danhong Injection combined with Xuebijing Injection has clinical curative effect in treatment of severe sepsis, and can obviously improve the life indicators, inflammation indexes and biochemical indexes, which has a certain clinical application value.