复方白及乳膏联合迈之灵片治疗肛裂的疗效观察

Clinical observation of Compound Baiji Cream combined with Aescuven Forte Tablets in treatment of anal fissure

目的观察复方白及乳膏联合迈之灵片治疗肛裂的临床疗效。方法选取2014年6月—2015年6月十堰市太和医院肛肠科收治的早期肛裂患者76例。按入选顺序排序编号,奇数为治疗组,偶数为对照组,每组各38例。对照组涂抹龙珠软膏,2次/d;治疗组涂抹复方白及乳膏,2次/d。两组患者同时口服迈之灵片,2片/次,2次/d。7 d为1个疗程,连续治疗2个疗程。观察两组的临床疗效,同时比较两组治疗前后便血消失时间、疼痛消失时间、创面愈合时间。结果治疗后,对照组和治疗组的治愈率分别为78.9%、92.1%,总有效率均为100.0%,两组治愈率比较差异具有统计学意义(P<0.05),但总有效率比较差异无统计学意义。治疗后,治疗组患者便血消失时间、疼痛消失时间、创面愈合时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。结论复方白及乳膏联合迈之灵片治疗肛裂具有较好的临床疗效,能显著改善临床症状,具有良好的临床应用价值。

Objective To observe the clinical effects of Compound Baiji Cream combined with Aescuven Forte Tablets in treatment of anal fissure. Methods Patients（76 cases） with early anal fissure in Department of Anus-intestines of Shiyan Taihe Hospital from June 2014 to June 2015 were divided into control and treatment groups according to the visiting single or even numbers, and each group had 38 cases. The patients in the control group were administered with Longzhu Ointment, twice daily. The patients in the treatment group were administered with Compound Baiji Cream, twice daily. The patients in two groups were po administered with Aescuven Forte Tablets 2 tablets/time, twice daily. Seven days was a course, and the patients in two groups were treated for 2 courses. After treatment, the clinical efficacies were evaluated, and the periods of healing pain, hemafecia, and wound healing in two groups before and after treatment were compared. Results After treatment, the cure rates in the control and treatment groups were 78.9% and 92.1%, respectively, and there were differences between two groups（P〈0.05）. And the clinical efficacies in two groups were both 100.0%, but there were no differences between two groups. After treatment, the periods of healing pain, hemafecia, and wound healing in the treatment group were significantly shorter than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Compound Baiji Cream combined with Aescuven Forte Tablets has clinical curative effect in treatment of anal fissure, can improve the clinical efficacies, which has a certain clinical application value.