NB-UVB联合酮康唑洗剂、伊曲康唑治疗马拉色菌毛囊炎疗效评价

Efficacy of NB-UVB combined with ketoconazole lotion and itraconazole in the treatment of moderate to severe Malassezia folliculitis

目的:评价NB-UVB联合酮康唑洗剂、伊曲康唑治疗中重度马拉色菌毛囊炎的疗效。方法:181例中重度马拉色菌毛囊炎患者,随机分为3组。A组58例,给予NB-UVB照射(每周3次)、2%酮康唑洗剂外洗(每天1次)及小剂量伊曲康唑口服(100 mg,日1次),治疗4周;B组60例,给予2%酮康唑洗剂外洗及小剂量伊曲康唑口服;C组63例,仅予小剂量伊曲康唑口服。结果:A、B、C组总有效率分别为91.38%、78.33%及61.90%,平均治愈时间分别为(27.80±3.15)天、(32.13±3.98)天及(35.83±3.42)天。结论:NB-UVB联合酮康唑洗剂在中重度马拉色菌毛囊炎治疗中能提高伊曲康唑疗效。

Objective： To assess the efficacy of NB- UVB combined with ketoconazole lotion and itraconazole in the treatment of moderate to severe Malassezia folliculitis. Methods： One hundred and eighty one outpatients with moderate to severe Malassezia folliculitis were divided into three groups randomly. Fifty eight patients in group A were treated with NB- UVB,ketoconazole lotion and oral itraconazole. Sixty patients in group B were treated with ketoconazole lotion and oral itraconazole. Sixty three patients in group C were treated with oral itraconazole only. NB- UVB was given 3 times,for 4 weeks,ketoconazole lotion once a day and itraconazole 100 mg,once a day for 4 weeks. Results： The total effective rates of group A,B and C was 91.38%,78. 33% and 61. 90% and the average cure time was（ 27. 80 ± 3. 15） / d,（ 32. 13 ± 3. 98） / d and（ 35.83 ± 3. 42） / d. Conclusion： NB- UVB combined with ketoconazole lotion and itraconazole is more effective than itraconazole alone in the treatment of moderate to severe Malassezia folliculitis.