胎盘多肽注射液联合维生素D治疗小儿哮喘的效果及对免疫功能的影响

The Effect Analysis and Immune Function Effect of Placenta Polypeptide Injection Combined with Vitamin D on the Treatment of Asthma Children

目的观察胎盘多肽注射液联合维生素D对哮喘患儿的治疗效果及对免疫功能的影响。方法选取2014-01—2015-01间在广东省吴川市妇幼保健院治疗的125例小儿哮喘患者作为研究对象,观察胎盘多肽注射液联合维生素D的治疗效果、不良反应发生情况以及对免疫功能的影响。结果 125例患儿在1年内哮喘的平均发作次数为（2.86±0.72）次,平均发作持续时间为（2.61±0.94）d,不良反应发生率为2.4%。125例患儿治疗1个月后与治疗3个月后免疫功能IgG、IgA、IgM等指标与治疗前相比明显升高,差异有统计学意义（P〈0.05）,IgE与治疗前相比明显降低,差异有统计学意义（P〈0.05）;治疗6个月后免疫功能IgG、IgA、IgM、IgE等指标与治疗前相比,差异无统计学意义（P〉0.05）;治疗6个月后免疫功能IgG、IgA、IgM、IgE等指标与治疗1个月后和3个月后相比,差异有统计学意义（P〈0.05）。结论胎盘多肽注射液联合维生素D治疗小儿哮喘效果显著,治疗1~3个月会对患儿的免疫功能产生影响,半年后恢复正常。

Objective To observe effect analysis and immune function effect of placenta polypeptide injection combined with Vitamin D on the treatment of asthma children and analyze the clinical application value.Methods 125 cases of asthma children,which admitted in our hospital during January 2014-January 2015,were selected as the research objects and the clinical data were retrospectively analyzed.Treatment effect,adverse reaction and effect on the immune function of placenta polypeptide injection combined with Vitamin D was observed.Results 125 cases of children in one year,average attack frequency was（ 2.86 ± 0.72） times,the average onset duration was（ 2.61 ± 0.94） d and the incidence of adverse reactions was 2.4%.Immunity IgG,IgA and IgM indicators of 125 cases children with 1month and 3 months after treatment were obviously higher than before treatment,the difference was statistically significant（ P〈0.05）.Immunity IgG,IgA and IgM indicators 6 months after treatment were not statistically significant（ P〈0.05）.Immunity IgG,IgA and IgM indicators 6 months compared with 1 month and 3 months after treatment was statistically significant（ P〈0.05）.Conclusion The placenta polypeptide injection combined with Vitamin D on the treatment of asthma children had obvious effect,1 month to 3 months treatment could affect the patient＇s immune function,and back to normal after half a year.