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脂联素与妊娠期糖尿病

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摘要 妊娠期糖尿病(gestational diabetes mellitus,GDM)是指在妊娠期间发生的糖代谢异常,其对母儿可产生严重的并发症,而胰岛素抵抗以及β细胞功能失调被认为是其主要的发病机制,但其分子机制并没有完全被阐明。脂联素(adiponectin,APN)是由脂肪细胞分泌的蛋白,它与代谢综合征及心血管疾病密切相关,肥胖可使其分泌失调。脂联素对GDM的发病也具有重要的作用。作者就脂联素在GDM中的调节以及在发病机制中可能发挥的作用进行综述。
出处 《现代医学》 2016年第3期419-425,共7页 Modern Medical Journal
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