长链非编码RNA在胰腺癌中的研究进展

Long non-coding RNAs in pancreatic cancer: recent advances

长链非编码RNA(lncRNAs)是一类转录本长度超过200nt、不具备蛋白编码功能的RNA分子。LncRNAs能够在表观遗传、基因转录水平以及转录后水平等不同层面发挥作用。此外,新近发现的微小RNA、环状RNA等可与lnc RNAs交互作用,参与恶性肿瘤的发生与发展过程。近年来,研究发现大量的lncRNAs异常表达于胰腺癌组织和细胞中,在胰腺癌的发生发展中也起着重要作用。因此,笔者就多种异常表达的lncRNAs在胰腺癌中的作用及机制进行综述。

Long non-coding RNAs（lncRNAs） are a class of RNA molecules with transcript length more than 200 nt and lack of protein coding capacity, which exert their actions by many layers at the epigenetic, transcription and posttranscription level. In addition, some newly discovered mi RNA and circ RNA are proven to interact with lncRNAs and thereby participate in the occurrence and development of cancer. In recent years, a large number of lncRNAs have been found exhibiting aberrant expression in pancreatic cancer tissue and cells, and playing a critical role in the occurrence and development of pancreatic cancer. Therefore, the authors address the issues concerning the effects and mechanisms of some lncRNAs that are aberrantly expressed in pancreatic cancer.