肝内胆管癌的大体类型与细胞来源的关系

Relation between macroscopic type and cellular origin of intrahe- patic cholangiocarcinoma

肝内胆管癌是原发性肝癌的一个重要组成部分，其发生发展的机制复杂。从细胞层面来分析，目前已被发现可能的来源有胆管上皮细胞、肝干细胞、肝细胞。从大体类型来分析，可将其分为以下三类：肿块型、管壁浸润型、腔内型。临床研究表明，不同类型的肝内胆管癌不仅形态学上有差异，患者的临床表现、治疗及预后差异也较大。因此，为探求肝内胆管癌的大体类型与细胞来源的关系，进一步研究清楚其相关发生机制及预后影响因素，笔者特就两者关系进行综述。

Intrahepatic cholangiocarcinoma, which occurrence and development involved kinds of cells and genes changes, is a vital part of the primary carcinoma of liver. The cellular origin may includes bile duct epithelial cells, hepatic stem cells and hepatic cells. The macroscopic type may includes： mass-forming types, periductal infihrating types, intraductal growth types. The fact was revealed that different macroscopic type of intrahepatie cholangioearcinoma has different clinical features, outcomes and prognosis. The author reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma, focusing especially on the macroscopic subtypes and related cell features, to discover the relation between macroscopic type and cellular origin of intrahepatic eholangiocarcinoma and better understand the pathogenesis of intrahepatic cholangiocarcinoma.