靶向治疗大肠癌的纳米药物及其载体进展

Advances in targeting nano drug therapy and its carrier of colorectal cancer

大肠癌是目前世界发病率第四位的恶性肿瘤，发病初期临床表现不明显，因此早期较难发现，诊断出时大多属于进展期。进展期的治疗多用化疗、介入治疗、放疗等方法，其中化疗在杀伤肿瘤细胞的同时，对正常机体细胞也有杀伤作用。近年来，各类新兴纳米靶向递送系统不断发展，由于纳米粒子可靶向定位于肿瘤组织，因而其在肠道肿瘤尤其是伴有转移的肠道肿瘤治疗中的应用越来越受到人们的重视。笔者针对目前纳米药物载体材料的类型、研究现状及其在大肠癌研究中的应用做一综述。

Colorectal cancer is currently the world＇s fourth incidence of malignant tumors, the early clinical manifestations are not obvious, so the early diagnosis is difficult to find, most of them are in progress. Treatment of advanced stage with chemotherapy, interventional therapy, radiotherapy and other methods, in which chemotherapy in the killing of tumor cells at the same time, the normal cells of the body also has a killing effect. In recent years, all kinds of new nano targeting delivery system has been developed, which can be targeted to the tumor tissue, so it is more and more important in the treatment of intestinal tumor, especially with metastasis. The author has made an overview of the types of nano drug Carrier materials, the research status and its application in the research of colorectal cancer.