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浆细胞多发性骨髓瘤合并继发性红细胞增多症1例并文献复习

A case of multiple myeloma with the secondary polycythemia and literature review
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摘要 多发性骨髓瘤(multiple myeloma,MM)属于造血系统恶性肿瘤,是浆细胞恶性增生产生M蛋白所致,多发生于50~70岁的老年人,随着老龄化的到来,其发病率呈逐年上升趋势。MM患者多数因骨痛,肾损害及贫血就诊,是肿瘤相关慢性病贫血的代表性疾病。我科近期收治1例MM合并继发性红细胞增多症患者,现报告如下,并进行相关文献复习,以提高临床医生对此类少见合并症的认识。 To explore clinical features,diagnosis and treatment of multiple myeloma with secondary polycythemia.We analyzed a case of multiple myeloma with the secondary polycythemia,and carried on the literature review.According to the clinical and related inspection,the patient was diagnosed.This disease is clinically rare,and we should strengthen the understanding of it.
机构地区 宁夏人民医院
出处 《临床血液学杂志》 CAS 2016年第2期246-247,共2页 Journal of Clinical Hematology
基金 宁夏自治区对外科技合作项目资助(No:宁科技字201420) 中央高校基金项目资助(No:31920140074)
关键词 多发性骨髓瘤 红细胞增多症 促红细胞生成素 multiple myeloma polycythemia erythropoietin
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参考文献5

  • 1De Luisi A,Binetti L,Ria R,et al.Erythropoietin is involved in the angiogenic potential of bone marrow macrophages in multiple myeloma[J].Angiogenesis,2013,16:963-973.
  • 2Kozan P,Chaalasani S,Handelsman DJ,et al.A leydig cell tumor of the ovary resulting in extreme hyper and rogenism erythrocytosis and recurrent pulmonary embolism[J].J Clin Endocrinol Metab,2014,99:12-17.
  • 3Lee SG,Lim G,Cho SY,et al.JAK2mutation-negative secondary erythrocytosis in smoldering plasma cell myeloma:a case study and review of the literature[J].Acta Haematol,2011,126:169-171.
  • 4Lombardero M,Kovacs K,Scheithauer BW,et al.Erythropoietin:a hormone with multiple functions[J].Pathobiology,2011,78:41-53.
  • 5马海佳,范玉平,陈彤,胡彩华,季美华.继发性红细胞增多症患者血清促红细胞生成素水平的变化[J].标记免疫分析与临床,2014,21(4):411-413. 被引量:4

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