职业性急性有机氟中毒救治要点分析

Key points in treatment of acute and severe occupational organic fluoride poisoning

目的通过综合分析3例职业性急性有机氟中毒病例的临床资料,总结职业性急性有机氟中毒救治过程中的经验和体会。方法对3例有机氟中毒患者的临床表现、实验室检查、影像学特征、主要治疗措施及转归进行分析。结果急性有机氟中毒以咳嗽、胸闷、气急为主要表现,影像学特征为两肺渗出性病变,予以早期足量及中晚期小剂量糖皮质激素、营养心肌等综合治疗,3例患者均治愈,随访3月未发生肺纤维化。结论在急性有机氟中毒的救治过程中,合理的激素治疗、保护重要脏器是治疗的重点。

Objective To summarize the clinical experience in treatment of 3 cases with occupational organic fluoride poisoning.Methods The clinical manifestations,laboratory examination,imaging features,major treatment protocols and efficacy of 3cases with occupational organic fluoride poisoning were comprehensively analyzed. Results Organic fluoride poisoning manifested cough,chest tightness,shortness of breath. The imaging examination showed typical characteristics of pulmonary exudative lesions. The appropriate use of glucocorticoids,full dose at early stage and small dose at middle and late stage,and myocardial nutrition therapy was very important. Three cases were cured without the occurrence of pulmonary fibrosis after treatment.Conclusion In the treatment of acute organic fluoride poisoning,appropriate hormone therapy,protection of important organs,attention to the occurrence of delayed pulmonary edema,should be the focus of treatment.