伴有高血压的非酒精性脂肪肝患者的糖耐量特点分析

Characteristics of glucose tolerance in patients with nonalcoholic fatty liver disease and high bloo pressure

目的：通过5点糖耐量及胰岛素释放试验分析伴有高血压的非酒精性脂肪肝（NAFLD）患者在糖代谢及胰岛素分泌、血脂等方面的特点。方法：收集2010年7月至2012年7月在本院体检科体检的NAFLD伴高血压患者50例及无高血压的NAFLD患者50例,比较及记录两组患者的一般资料,5点葡萄糖耐量及胰岛素释放试验结果,血脂、尿酸、ALT水平。结果：伴有高血压的NAFLD患者糖代谢异常发生率高于无高血压患者,两组在糖代谢异常发生率方面比较差异有统计学意义,伴有高血压的NAFLD患者30 min胰岛素分泌呈现减低现象,180 min胰岛素分泌呈现相对高水平,两组比较差异有统计学意义（P〈0.05）,从总体趋势上看,虽差异无统计学意义,但高血压组与无高血压组比较胰岛素分泌在30~120 min呈现减低趋势,三酰甘油在高血压组明显升高（P〈0.05）。结论：伴有高血压的NAFLD患者的糖代谢异常发生率高于无高血压的NAFLD患者,同时存在早相胰岛素分泌减低及胰岛素分泌延迟现象。

Objective To investigate glucose metabolism, insulin secretion and serum lipid in patients of nonalcoholic fatty liver disease（NAFLD） with hypertension. Methods A total of 100 subjects including NAFLD with hypertension（n = 50） and NAFLD without hypertension（n = 50）, in our hospital during Jul.2010 to Jul. 2012, were enrolled in this study. Records the following information of the two groups ： The clinical data, oral glucose tolerance and insulin releasing test, serum lipid, serum uric acid and ALT were recorded. Results Compared with the NAFLD without hypertension group, impaired glucose regulation was significantly increased in patients in the NAFLD with hypertension group（P〈0.05）.The insulin releasing was significantly increased at 30 min and was increased at 180 min in patients in the NAFLD with hypertension group（P〈0.05）.The insulin releasing during 30 min to 120 min was descend gradually in patients in the NAFLD with hypertension group,with no significant difference between these two groups. TG was markedly elevated in patients in the NAFLD with hypertension group（P〈0.05）. Conclusion Prevalence of impaired glucose regulation was elevated obviously in NAFLD with hypertension group,and early-phase insulin secretion were reduced and delayed.