缺血性脑血管病患者脑微出血的危险因素分析

Rrisk factors of cerebral microbleeds in patients with ischemic cerebrovascular disease

目的 探讨缺血性脑血管病患者脑微出血的危险因素.方法 收集2012年1月至2014年1月在首都医科大学附属北京安贞医院住院的182例缺血性脑血管病患者的临床资料,行头部磁共振磁敏感加权成像,根据是否合并脑微出血分为脑微出血组（62例）和非脑微出血组（120例）,分析脑微出血的危险因素.结果 脑微出血组患者合并高血压史比例、腔隙性脑梗死灶数目和脑白质疏松程度评分均明显高于非脑微出血组[69.4％ （43/62）比50.0％（60/120）、（5.5±2.1）个比（2.2±1.0）个、（5.7±1.7）分比（2.5±1.1）分],差异均有统计学意义（均P＜0.05）.多因素Logistic回归分析显示,合并高血压、腔隙性脑梗死和脑白质疏松是缺血性脑血管病患者脑微出血的危险因素（均P ＜0.05）.结论 合并高血压、腔隙性脑梗死数目和脑白质疏松程度是缺血性脑血管病患者脑微出血的危险因素.

Objective To analyze the risk factors of cerebral microbleeds （CMBs） in patients with ischemic cerebrovascular disease.Methods Totally 182 patients with ischemic cerebrovascular disease from January 2012 to January 2014 were collected;according to the results of magnetic resonance susceptibility weighted imaging,the patients were divided into CMBs group （62 cases） and non-CMBs group （120 cases）.The risk factors of CMBs in patients with ischemic cerebrovascular disease were analyzed.Results The proportion of hypertension,lesion number of lacunar infarction and leukoaraiosis degree in CMBs group were significantly higher than those in non-CMBs group [69.4% （43/62） vs 50.0% （60/120）,（5.5 ±2.1） vs （2.2 ± 1.0）,（5.7 ± 1.7） scores vs （2.5 ± 1.1） scores] （P 〈 0.05）.Logistic stepwise regression analysis showed that hypertension,lacunar infarction and leukoaraiosis were independent risk factors of CMBs in patients with ischemic cerebrovascular disease.Conclusion Hypertension,lacunar infarction and leukoaraiosis were independent risk factors of cerebral microbleeds in patients with ischemic cerebrovascular disease.