雷贝拉唑、呋喃唑酮及阿莫西林三联疗法对萎缩性胃炎伴幽门螺旋杆菌感染患者血清SOD、MDA、GSH-Px水平的影响

Effect of triple therapy of rabeprazole,furazolidone and amoxicillin on serum SOD,MDA and GSH-Px levels in atrophic gastritis patients with Helicobacter pylori infection

目的 探讨雷贝拉唑、呋喃唑酮及阿莫西林三联疗法对萎缩性胃炎伴幽门螺旋杆菌感染患者血清超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）水平的影响。方法 选取2013年10月~2015年9月入住嘉兴市第一医院消化科的萎缩性胃炎伴幽门螺旋杆菌感染患者120例,随机分为实验组和对照组,各60例。对照组患者使用奥美拉唑进行治疗,实验组患者使用雷贝拉唑、呋喃唑酮及阿莫西林三联疗法进行治疗。比较治疗前后2组患者血清SOD、MDA、GSH-Px水平,比较治疗结束后2组临床总有效率、Hp转阴率。结果 治疗结束后,与对照组相比,实验组血清SOD、GSH-Px水平较高,MDA水平较低（P〈0.05）。实验组临床总有效率显著高于对照组[57（95.00）vs.50（83.33）,χ2=4.23,P〈0.05]。实验组患者的Hp转阴率显著高于对照组[56（93.33%）vs.48（80.00%）,χ2=4.62,P〈0.05]。结论 雷贝拉唑、呋喃唑酮及阿莫西林三联疗法能够提高萎缩性胃炎伴幽门螺旋杆菌感染的临床总有效率及Hp根除率,推测其机制可能与升高SOD、GSH-Px水平,降低MDA水平有关。

Objective To investigate the effect of triple therapy of rabeprazole, furazolidone and amoxicillin on serum superoxide dismutase （SOD）, malonaldehyde （MDA） and glutathione peroxidase （GSH-Px） levels in atrophic gastritis patients with Helicobacter pylori infection. Methods 120 atrophic gastritis patients with Helicobacter pylori infection from October 2013 to September 2015 in our hospital were selected and randomly divided into the control group and experimental group with 60 cases in each group. The control group received omeprazole and the experimental group received triple therapy of rabeprazole, furazolidone and amoxicillin. The SOD, MDA, GSH-Px , the total clinical efficiency and the negative rate of Hp were compared. Results After treatment, compared with control group, the SOD and GSH-Px levels were higher, the MDA level were lower in experimental group（P 〈0. 05）. The total effective rate in experimental group was higher than that in control group[ 57 （95.00）vs. 50（83.33） ,X2 = 4. 23,P 〈 0. 05 ]. The negative rate of Hp in experimental group was higher than that in control group [ 56 （93. 33% ）vs. 48 （80. 00% ） ,X2 = 4. 62, P 〈 0. 05 ]. Conclusion Triple therapy of rabeprazole, furazolidone and amoxicillin could improve clinical total efficiency and Hp eradication rate of atrophic gastritis patients with Helicobacter pylori infection, suggesting that the possible mechanisms may be to increase SOD and GSH Px levels and decrease MDA level.