亚胺培南/西司他丁对重症肺炎患者血清CRP及降钙素原水平影响研究

Effect of imipenem/cilastatin on CRP and procalcitonin in treatment of patients with severe pneumonia

目的探讨亚胺培南/西司他丁对重症肺炎患者血清CRP及降钙素原水平的影响。方法选取治疗的重症肺炎患者96例作研究对象,按抗生素药物治疗不同分组,对照组45例采用头孢哌酮/舒巴坦治疗,研究组51例采用亚胺培南/西司他丁治疗。比较2组间治疗后临床疗,CRP、PCT及WBC水平。结果研究组治疗后临床疗效有效率(88.24%)显著高于对照组治疗后临床疗效有效率(71.11%)(P<0.05)。与治疗前比较,2组治疗1周、治疗后CRP、PCT及WBC水平均显著下降(P<0.05),研究组治疗1周、治疗后CRP、PCT及WBC水平低于对照组治疗1周、治疗后CRP、PCT及WBC水平。结论亚胺培南.两司他丁能降低重症肺炎患者血清CRP及降钙素原水平,效果显著。

Objective To explore the influence of imipenem and cilastatin on serum CRP and procalcitonin level in treatment of patients with severe pneumonia. Methods Ninety-six severe pneumonia patients in ICU treatment were divided as per different treatment of antibiotic medicine. Forty-five patients in control group were treated with sulbactam and cefopcrazone, while fifty-one patients in study group were treated with Imipenem and Cilastatin. Clinical efficacy and levels of CRP, PCT and WBC were compared before and after the treatment. Results After treatment, the clinical efficacy rate （88.24%） of study group was significantly higher than that of control group （71. 11% , （P 〈 0.05 ）. Compared with the situation before treatment, the levels of CRP, PCT and WBC in both groups were significantly reduced after one-week treatment and after treatment. The levels of CRP, PCT and WBC in study group after one-week treatment and after treatment were lower than those in control group with statistical significance （ P 〈 0.05 ）. Conclusion Imipenem and cilastatin can reduce serum CRP and proealeitonin level of severe pneumonia patients, and the efficacy is significant.