蚓激酶治疗脑梗死的临床效果观察

Clinical effects of lumbrokinase in the treatment of cerebral infarction

目的 观察蚓激酶治疗脑梗死的临床效果。方法 选取2014年2月~2015年2月收治的诊断为脑梗死的患者80例,按随机数字表法分为观察组和对照组,每组各40例。对照组给以常规药物治疗,观察组在对照组的基础上给以蚓激酶治疗,分析治疗结束后2组患者纤维蛋白原含量,血小板聚集率,全血黏度,血浆黏度以及临床疗效状况。结果 2组患者治疗前纤维蛋白原含量,血小板聚集率,全血黏度,血浆黏度无统计学意义;蚓激酶可以有效改善全血黏度,降低纤维蛋白原含量,从而降低血浆黏度以及血小板聚集率（P〈0.05）;治疗前,2组患者NIHSSS评分和ADL评分差异无统计学意义,治疗后2组患者神经功能缺损程度的评分（NIHSS评分）明显降低,日常生活能力评分（ADL评分）明显升高,且观察组明显优于对照组（P〈0.05）。与对照组相比,观察组患者治疗的总有效率明显更高（P〈0.05）。结论 蚓激酶治疗脑梗死的临床效果确切且与常规对症治疗相比,值得临床进一步深入研究和推广。

Objective To observe clinical effects of lumbrokinase in the treatment of cerebral infarction. Methods 80 cases were diagnosed with cerebral infarction and divided into observation group（ n = 40） and control group （n = 40） from February 2014 to February 2015. According to random number table method, control group was given routine drug treatment, observation group was given vermis kinase treatment on the basis of control group, analysed content of fibrinogen,platelet aggregation rate, whole blood viscosity, plasma viscosity and the clinical curative effect between two groups post- treatment. Results No statistical significance of fibrinogen levels and platelet aggregation rate, whole blood viscosity, plasma viscosity between two groups pre-treatment. Compared with control group post-treatment,vermis kinase improved the whole blood viscosity, reduced the content of fibrinogen, reduced blood viscosity and platelet aggregation rate （ P 〈 0.05 ）. pre-treatment, two groups of patients NIHSSS scores and ADL scores had no significant difference. Two groups post-treatment, the degree of nerve function defect score （NIHSS score） decreased obviously（P 〈0. 05 ）, daily life ability score （ADL score） increased significantly （P 〈 0. 05 ）, and the observation group was better than control group （P 〈 0. 05 ）. Compared with control group post- treatment, the total effective rate of observation group was obviously higher（P 〈 0. 05 ）. Conclusion Clinical effect of lumbrokinase in treatment of cerebral infarction is definite, compares with the conventional symptomatic treatment, it is worthy of further study and promotion.