摘要
目的探讨冠心病患者血清对氧磷酶1(PON1)与脂蛋白磷脂酶A_2(LP-PLA_2)活性与冠脉病变支数及斑块稳定性的相关性。方法入选88例冠心病患者为研究组,同期行冠状动脉造影术(CAG)排除冠心病的32例患者为对照组。检测两组患者血清PON1、LP-PLA_2活性,对PON1、LP-PLA_2活性与冠状动脉病变支数及斑块稳定性进行相关性分析。结果冠心病患者血清PON1活性明显低于对照组(P<0.05);活性均值随冠状动脉病变支数增加而降低(P<0.05);在斑块不稳定组PON1活性明显低于斑块稳定组(P<0.05)。冠心病患者血清LP-PLA_2活性均值明显高于对照组(P<0.05),随冠状动脉病变支数增加而升高(P<0.05),且与患者总胆固醇、低密度脂蛋白水平呈正相关。结论血清PON1及LP-PLA_2活性与冠心病的发生及冠状动脉病变支数有相关性,PON1活性降低可作为冠状动脉斑块趋于不稳定的观察指标。
Objective To study the relationship between serum PON1 and LP-PLA2 activity of coronary artery lesions and plaque stability in patients with coronary heart disease. Methods According to the coronary angiography results, the patients were divided into coronary heart disease group（n=88） and control（n=32）.Serum PON1 and LP-PLA2 activity among groups were compared.Relationship between PON1,LP-PLA2 activity and coronary lesions degree and plaque stability was analysed. Results The serum PON1 activity of coronary heart disease group was significantly lower than the control group（P〈0.05）. PON1 activity decreased with increasing coronary lesion count（P〈0.05）. The unstable plaque group was obviously lower than that of PON1 activity in the stable plaque group（P〈0.05）. LP-PLA2 activity levels in the team significantly were higher than the control group（P〈0.05）. LP-PLA2 activity increased with increasing coronary lesion count（P〈0.05）. LP-PLA2 activity was positively correlated with total cholesterol and LDL levels. Conclusion Serum PON1 and LP-PLA2 activity correlated with the incidence of coronary heart disease and coronary artery lesion count. PON1 activity can be used as observation index of coronary plaque stability.
出处
《医学研究杂志》
2016年第3期108-111,共4页
Journal of Medical Research
基金
上海申康市级医院适宜技术推广应用项目(SHDC12012210)
上海市宝山区科技发展基金资助项目(12-E-63)
