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MTA2在头颈部鳞癌中的研究进展

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摘要 转移相关蛋白2(Metastasis—associated protein2,MTA2)是近些年发现的肿瘤转移相关蛋白家族的成员之一,是核小体重塑的核心组件并在组蛋白的去乙酰化中起着复杂的作用,MTA2是细胞骨架组织和转录的中央枢纽,并为细胞核和细胞骨架组织提供联系。目前MTA2在乳腺癌、扁桃体癌、肺癌等恶性肿瘤中的研究颇多,但在头颈部鳞癌中的研究报道目前还较少。本文通过对MTA家族的研究概况、其介导肿瘤转移的分子机制进行复习,同时对MTA2在头颈部鳞癌的研究前景进行展望,旨在为该类疾病的诊疗提供新思路。
作者 宋辉 张俊杰
出处 《医学临床研究》 CAS 2016年第3期554-557,共4页 Journal of Clinical Research
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