应激状态下机体与肠道菌群的相互作用及天然多酚干预作用研究

Interactions between intestinal flora and body induced by stress and the effects of intervention with natural polyphenols

机体长期处于应激状态下,导致焦虑和抑郁等精神疾病的发病率不断上升,严重威胁着人类健康和社会发展。许多研究表明应激会导致肠道菌群的紊乱,影响神经通路发生精神性疾病、使细菌移位产生免疫炎症。天然多酚类化合物具有多种生物活性,但绝大部分难以直接进入体内,而是在肠道中被肠道菌群降解。多酚可以调整机体应激反应状态下被扰乱的肠道菌群的组成和结构,使之恢复动态平衡,进而改善机体各种应激因素所致的焦虑和抑郁等症状。

The rising incidence of anxiety and depression and other mental illnesses caused by the body′s stress response for a long time poses a serious threat to human health and social development.Many studies have shown that stress can lead to intestinal flora disorder,and mental diseases by affecting neural pathways,as well as immune inflammation by inducing bacterial translocation.Natural polyphenols compounds have a variety of physiological activities.Most of polyphenols are degraded by intestinal flora in the intestinal tract before being absorbed in the forms of their prototypes.Polyphenols can adjust the compositions and structures of disturbed intestinal flora in body under stress response condition,restore the dynamic balance,as well as improve the body′s symptoms such as anxiety and depression caused by various stress factors.