祛湿通痹汤联合MTX治疗类风湿性关节炎患者血清中IL-1及TNF-α表达的影响

Effect of Qushi Tongbi Decoction Combined with MTX on Expressions of IL-1 and TNF-α in Patients with Rheumatoid Arthritis

目的:观察祛湿通痹汤联合甲氨蝶呤(MTX)对类风湿关节炎患者血清中IL-1及TNF-α水平的影响。方法:选取2014年1月—2015年6月医院收治的82例类风湿关节炎患者作为研究对象,随机分为治疗组(41例)和对照组(41例),对照组口服MTX,治疗组在此基础上加服祛湿通痹汤联合治疗,观察治疗前后患者细胞因子IL-1、TNF-α及红细胞沉降率(ESR)、C反应蛋白(CRP)的变化,记录患者治疗总有效率。结果:治疗组总有效率82.9%显著高于对照组58.5%,差异有统计学意义(P<0.05);两组患者治疗1周和2周后,IL-1及TNF-α值与治疗前比较,均有显著性降低(P<0.05);且治疗2周后治疗组各指标与对照组比较降低显著(P<0.05);两组治疗1周、2周后的ESR、CRP值较治疗前有显著性降低(P<0.05);并且治疗组与对照组比较其值降低更加显著(P<0.05)。结论:祛湿通痹汤联合MTX治疗类风湿关节炎患者疗效确切,能有效抑制IL-1及TNF-α的表达。

Objective： To observe the effect of Qushi Tongbi Decoction combined with MTX on expression levels of IL-1 and TNF-α in patients with rheumatoid arthritis.Methods： From January 2014 to June 2015,82 RA patients,as the research object,were assigned to the treatment group（ 41 cases） and the control group（ 41 cases）.Patients in control group were treated by MTX and the treatment group by Qushi Tongbi Decoction combined with MTX.The expression levels of IL-1,TNF-α,ESR and CRP were detected before treatment,1 and 2 weeks after treatment.Results： The effective rate of the treatment group was 82.9%,significantly higher than the control group＇s 58.5%（ P〈0.05）.After one or two weeks treatment,IL-1 and TNF-α in treatment group were lower than those before treatment and those of control group（ P〈0.05）.After two weeks treatment,ESR and CRP reduced more in the treatment group than those before treatment and those of control group（ P〈0.05）.Conclusion： Qushi Tongbi Decoction combined MTX has curative effect in patients with arthritis and can effectively inhibit the expressions of IL-1 and TNF-α.