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托芬那酸肌注后在犬体内的药物代谢动力学研究 被引量:4

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摘要 建立用于检测犬血浆中托芬那酸浓度的高效液相色谱法,并对犬单次肌肉注射托芬那酸注射液后的药物代谢动力学特征进行研究。选用6只健康成年拉布拉多犬,按4 mg·kg-1剂量单次肌肉注射托芬那酸注射液,血浆样品经甲醇沉蛋白、高速离心后,取上清用反相高效液相色谱法进行检测;用3p97药动学软件对药物浓度-时间数据进行分析。结果显示:健康试验犬肌肉注射后的药物代谢动力学过程符合一级吸收二室开放模型,其主要药动学参数为:药时曲线下面积(AUC)为(9.57±1.30)μg·h·m L-1,清除率(CL)为(0.51±0.20)L/h/kg,达峰时间(Tpeak)为(0.35±0.11)h,峰浓度(Cmax)为(4.10±0.45)μg·m L-1,消除半衰期(t1/2β)为(5.71±2.21)h,吸收半衰期(t1/2α)为(0.66±0.20)h。结果表明:犬肌肉注射托芬那酸后,吸收快,在血浆中能迅速达到血药高峰且达峰浓度高,起效迅速。
出处 《畜牧与兽医》 北大核心 2016年第2期67-70,共4页 Animal Husbandry & Veterinary Medicine
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共引文献27

同被引文献32

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