Effect of electroacupuncture at ear and body acupoints on the instant fasting blood glucose level of machins with type 2 diabetes mellitus

电针耳穴体穴对2型糖尿病猴即时空腹血糖的影响(英文)

Objective To observe the effect of electroacupuncture at ear and body acupoints for the instant fasting blood glucose of model machins with type 2 diabetes mellitus（T2DM）.Methods For 10 machins with type2 diabetes,the electroacupuncture was applied at ＂Zusanli＂（足三里 ST 36）,＂Sanyinjiao＂（三阴交 SP 6） and three ＂Jiangtangdian＂（降糖点） in the ear continuously for 5 days,with the frequency of 2/15 Hz（The 2 Hz and the 15 Hz were transferred every second） and current of2 mA.The treatment was given once every day for 30 min.The fasting blood glucose was measured before acupuncture,after acupuncture for15 min and 30 min in the 5 days.Results On the first day,after 30-minute acupuncture the fasting blood glucose was reduced obviously compared with that before treatment（P〈0.01）.On the third and the fifth days,after acupuncture for 15 min and 30 min the fasting blood glucose was apparently lower than that before acupuncture（all P〈0.05）.On the fourth day,after acupuncture for 30 min the fasting blood glucose was decreased markedly than that before acupuncture（P〈0.05）.After 30-minute acupuncture on the fifth day,the fasting blood glucose was lower obviously than that before treatment on the first day（P〈0.05）.Conclusion ①The electroacupuncture at ear and body acupoints can reduce the instant fasting blood glucose of T2 DM machins apparently.② There is time effect on instant fasting blood glucose of T2 DM machins treated by electroacupuncture.The efficacy of 30-minute stimulation is superior to that of 15-minute acupuncture.After acupuncture continuously for 4 days,the effect is better than that with acupuncture for3 days successively.

目的:观察电针耳穴体穴对2型糖尿病(T2DM)模型猴即时空腹血糖的影响。方法:10只2型糖尿病模型猴均行电针干预,选取"足三里""三阴交"耳穴"降糖点"三穴同时电针干预,持续5天,频率2/15 Hz(2 Hz和15 Hz,每秒转换),强度2 mA,每天1次,每次30 min。测量针刺前、针刺15 min和针刺30min空腹血糖。结果:第1天针刺30 min,T2DM模型猴的空腹血糖与针刺前相比,有显著降低且差异具有统计学意义(P<0.01);第3、5天针刺15 min与30 min,T2DM模型猴的空腹血糖与针刺前相比,均有显著降低且差异具有统计学意义(P<0.05);第4天针刺30 min,T2DM模型猴的空腹血糖与针刺前相比,有显著降低且差异具有统计学意义(P<0.05);第5天针刺30min后,T2DM模型猴的空腹血糖与第1天针刺前相比,下降明显,经统计具有显著性差异(P<0.05)。结论:(1)电针耳穴体穴对T2DM模型猴即时空腹血糖有显著降低作用;(2)电针刺激对T2DM模型猴即时空腹血糖的干预具有时间效应,针刺30min效果明显优于15 min;连续刺激4天及以上,效果明显优于连续刺激3天及以下。